Identity
HGNC
LOCATION
Xq28
LOCUSID
ALIAS
C1,RGC1,RhoGAP4,SrGAP4,p115
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 393
MIM: 300023
HGNC: 674
Ensembl: ENSG00000089820
Variants:
dbSNP: 393
ClinVar: 393
TCGA: ENSG00000089820
COSMIC: ARHGAP4
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by Rho GTPases | REACTOME | R-HSA-194315 |
| Rho GTPase cycle | REACTOME | R-HSA-194840 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38905034 | 2024 | Rho GTPase-activating protein 4 is upregulated in Kidney Renal Clear Cell Carcinoma and associated with poor prognosis and immune infiltration. | 0 |
| 38905034 | 2024 | Rho GTPase-activating protein 4 is upregulated in Kidney Renal Clear Cell Carcinoma and associated with poor prognosis and immune infiltration. | 0 |
| 37443303 | 2023 | ARHGAP4 promotes leukemogenesis in acute myeloid leukemia by inhibiting DRAM1 signaling. | 0 |
| 37443303 | 2023 | ARHGAP4 promotes leukemogenesis in acute myeloid leukemia by inhibiting DRAM1 signaling. | 0 |
| 36288877 | 2022 | Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the Development of Scirrhous-type Gastric Cancer. | 2 |
| 36288877 | 2022 | Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the Development of Scirrhous-type Gastric Cancer. | 2 |
| 34524873 | 2021 | ARHGAP4-SEPT2-SEPT9 complex enables both up- and down-modulation of integrin-mediated focal adhesions, cell migration, and invasion. | 3 |
| 34524873 | 2021 | ARHGAP4-SEPT2-SEPT9 complex enables both up- and down-modulation of integrin-mediated focal adhesions, cell migration, and invasion. | 3 |
| 32378260 | 2020 | Comprehensive analysis on the whole Rho-GAP family reveals that ARHGAP4 suppresses EMT in epithelial cells under negative regulation by Septin9. | 14 |
| 32378260 | 2020 | Comprehensive analysis on the whole Rho-GAP family reveals that ARHGAP4 suppresses EMT in epithelial cells under negative regulation by Septin9. | 14 |
| 30958531 | 2019 | ARHGAP4 regulates the cell migration and invasion of pancreatic cancer by the HDAC2/β-catenin signaling pathway. | 17 |
| 30958531 | 2019 | ARHGAP4 regulates the cell migration and invasion of pancreatic cancer by the HDAC2/β-catenin signaling pathway. | 17 |
| 26707211 | 2016 | ARHGAP4 mutated in a Chinese intellectually challenged family. | 4 |
| 26707211 | 2016 | ARHGAP4 mutated in a Chinese intellectually challenged family. | 4 |
| 24043878 | 2014 | Common variants on Xq28 conferring risk of schizophrenia in Han Chinese. | 20 |
Citation
Dessen P
ARHGAP4 (Rho GTPase activating protein 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/696/arhgap4
