ARID4A (AT-rich interaction domain 4A)

2003-02-01  

Identity

HGNC
ARID4A
LOCATION
14q23.1
LOCUSID
5926
ALIAS
RBBP-1,RBBP1,RBP-1,RBP1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5926
MIM: 180201
HGNC: 9885
Ensembl: ENSG00000032219

Variants:

dbSNP: 5926
ClinVar: 5926
TCGA: ENSG00000032219
COSMIC: ARID4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000032219ENST00000348476P29374
ENSG00000032219ENST00000348476A0A024R680
ENSG00000032219ENST00000355431P29374
ENSG00000032219ENST00000355431A0A024R657
ENSG00000032219ENST00000395168P29374
ENSG00000032219ENST00000395168A0A024R6A2
ENSG00000032219ENST00000417477H7C485
ENSG00000032219ENST00000424658C9JIF4
ENSG00000032219ENST00000431317P29374
ENSG00000032219ENST00000431317A0A024R680
ENSG00000032219ENST00000431612F8WAR5
ENSG00000032219ENST00000445108C9J1W3

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815

References

Pubmed IDYearTitleCitations
353658082022A novel heterozygous missense variant of the ARID4A gene identified in Han Chinese families with schizophrenia-diagnosed siblings that interferes with DNA-binding activity.0
353658082022A novel heterozygous missense variant of the ARID4A gene identified in Han Chinese families with schizophrenia-diagnosed siblings that interferes with DNA-binding activity.0
345067902021Structural Insight into Chromatin Recognition by Multiple Domains of the Tumor Suppressor RBBP1.3
345067902021Structural Insight into Chromatin Recognition by Multiple Domains of the Tumor Suppressor RBBP1.3
294085272018Crystal structure of chromo barrel domain of RBBP1.1
297976002018Downregulation of ARID4A and ARID4B promote tumor progression and directly regulated by microRNA-30d in patient with prostate cancer.8
294085272018Crystal structure of chromo barrel domain of RBBP1.1
297976002018Downregulation of ARID4A and ARID4B promote tumor progression and directly regulated by microRNA-30d in patient with prostate cancer.8
243793992014Retinoblastoma-binding protein 1 has an interdigitated double Tudor domain with DNA binding activity.6
243793992014Retinoblastoma-binding protein 1 has an interdigitated double Tudor domain with DNA binding activity.6
222475512012Structural insight into recognition of methylated histone tails by retinoblastoma-binding protein 1.10
227321862012Reactive oxygen species mediate microRNA-302 regulation of AT-rich interacting domain 4a and C-C motif ligand 5 expression during transitions between quiescence and proliferation.5
222475512012Structural insight into recognition of methylated histone tails by retinoblastoma-binding protein 1.10
227321862012Reactive oxygen species mediate microRNA-302 regulation of AT-rich interacting domain 4a and C-C motif ligand 5 expression during transitions between quiescence and proliferation.5
182119002008Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cells.39

Citation

Dessen P

ARID4A (AT-rich interaction domain 4A)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/703/meetings/js/gene-explorer/