MRPS6 (mitochondrial ribosomal protein S6)

2014-11-01  

Identity

HGNC
MRPS6
LOCATION
21q22.11
LOCUSID
64968
ALIAS
C21orf101,MRP-S6,RPMS6,S6mt
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64968
MIM: 611973
HGNC: 14051
Ensembl: ENSG00000243927

Variants:

dbSNP: 64968
ClinVar: 64968
TCGA: ENSG00000243927
COSMIC: MRPS6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000243927ENST00000399312P82932

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RibosomeKEGGko03010
RibosomeKEGGhsa03010
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial translationREACTOMER-HSA-5368287
Mitochondrial translation initiationREACTOMER-HSA-5368286
Mitochondrial translation elongationREACTOMER-HSA-5389840
Mitochondrial translation terminationREACTOMER-HSA-5419276

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377588222023MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response.0
377588222023MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response.0
339643762021Mitochondrial ribosomal small subunit proteins (MRPS) MRPS6 and MRPS23 show dysregulation in breast cancer affecting tumorigenic cellular processes.8
339643762021Mitochondrial ribosomal small subunit proteins (MRPS) MRPS6 and MRPS23 show dysregulation in breast cancer affecting tumorigenic cellular processes.8
207389372010Additive effect of multiple genetic variants on the risk of coronary artery disease.9
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
209713642010A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.233
207389372010Additive effect of multiple genetic variants on the risk of coronary artery disease.9
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
209713642010A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.233
191986092009Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.534
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.94
191986092009Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.534
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.94

Citation

Dessen P

MRPS6 (mitochondrial ribosomal protein S6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70492/gene-fusions/js/lib/jquery-3.5.1.min.js