MTCH2 (mitochondrial carrier 2)

2014-11-01  

Identity

HGNC
MTCH2
LOCATION
11p11.2
LOCUSID
23788
ALIAS
HSPC032,MIMP,SLC25A50
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23788
MIM: 613221
HGNC: 17587
Ensembl: ENSG00000109919

Variants:

dbSNP: 23788
ClinVar: 23788
TCGA: ENSG00000109919
COSMIC: MTCH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109919ENST00000302503Q9Y6C9
ENSG00000109919ENST00000530428E9PIE4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381581522024The biology of mitochondrial carrier homolog 2.0
381779002024MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion.1
387278662024The mitochondrial carrier homolog 2 is involved in down-regulation of influenza A virus replication.0
381581522024The biology of mitochondrial carrier homolog 2.0
381779002024MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion.1
387278662024The mitochondrial carrier homolog 2 is involved in down-regulation of influenza A virus replication.0
359044512023Opposing effects of genetic variation in MTCH2 for obesity versus heart failure.2
359044512023Opposing effects of genetic variation in MTCH2 for obesity versus heart failure.2
335090922021Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma.10
345863462021The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis.19
335090922021Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma.10
345863462021The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis.19
320945112020MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.20
322991042020Mitochondrial carrier homolog 2 is necessary for AML survival.15
330286342020Stop codon read-through of mammalian MTCH2 leading to an unstable isoform regulates mitochondrial membrane potential.5

Citation

Dessen P

MTCH2 (mitochondrial carrier 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70536/gene-fusions/favicon/manifest.json