MYLIP (myosin regulatory light chain interacting protein)

2014-11-01  

Identity

HGNC
MYLIP
LOCATION
6p22.3
LOCUSID
29116
ALIAS
IDOL,MIR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29116
MIM: 610082
HGNC: 21155
Ensembl: ENSG00000007944

Variants:

dbSNP: 29116
ClinVar: 29116
TCGA: ENSG00000007944
COSMIC: MYLIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007944ENST00000349606Q5TIA5
ENSG00000007944ENST00000356840Q8WY64

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
VLDL interactionsREACTOMER-HSA-8855121
VLDLR internalisation and degradationREACTOMER-HSA-8866427

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444516HypercholesterolemiaDiseaseClinicalAnnotationassociatedPD25171759
PA448500atorvastatinChemicalClinicalAnnotationassociatedPD25171759

References

Pubmed IDYearTitleCitations
370474062023Mouse Spinal Cord Vascular Transcriptome Analysis Identifies CD9 and MYLIP as Injury-Induced Players.1
370946392023Effect of type 2 diabetes on the inducible degrader of LDL receptor.0
370474062023Mouse Spinal Cord Vascular Transcriptome Analysis Identifies CD9 and MYLIP as Injury-Induced Players.1
370946392023Effect of type 2 diabetes on the inducible degrader of LDL receptor.0
331541642021SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1.6
331855882021Identification of MYLIP gene and miRNA-802 involved in the growth and metastasis of cervical cancer cells.12
334506932021Novel associations of SNPs MYLIP rs3757354 and ABCA1 2230806 gene with early-onset-preeclampsia: A case-control candidate genetic study.0
338458902021Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China.2
331541642021SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1.6
331855882021Identification of MYLIP gene and miRNA-802 involved in the growth and metastasis of cervical cancer cells.12
334506932021Novel associations of SNPs MYLIP rs3757354 and ABCA1 2230806 gene with early-onset-preeclampsia: A case-control candidate genetic study.0
338458902021Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China.2
327278442020Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site.3
328688612020IDOL gene variant is associated with hyperlipidemia in Han population in Xinjiang, China.3
327278442020Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site.3

Citation

Dessen P

MYLIP (myosin regulatory light chain interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70619