NPW (neuropeptide W)

2014-11-01  

Identity

HGNC
NPW
LOCATION
16p13.3
LOCUSID
283869
ALIAS
L8,L8C,PPL8,PPNPW

Other Information

Locus ID:

NCBI: 283869
MIM: 607997
HGNC: 30509
Ensembl: ENSG00000183971

Variants:

dbSNP: 283869
ClinVar: 283869
TCGA: ENSG00000183971
COSMIC: NPW

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183971ENST00000566435H3BT17
ENSG00000183971ENST00000567649H3BT42

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
pituitary gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
265360902015Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7.10
265360902015Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7.10
252702692014Gastric neuropeptide W is regulated by meal-related nutrients.5
252702692014Gastric neuropeptide W is regulated by meal-related nutrients.5
228267472011Analgesic neuropeptide W suppresses seizures in the brain revealed by rational repositioning and peptide engineering.9
228267472011Analgesic neuropeptide W suppresses seizures in the brain revealed by rational repositioning and peptide engineering.9
127195372003Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.51
129599972003A role for neuropeptide W in the regulation of feeding behavior.22
127195372003Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.51
129599972003A role for neuropeptide W in the regulation of feeding behavior.22
121306462002Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.38
121306462002Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.38

Citation

Dessen P

NPW (neuropeptide W)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70956