NRXN2 (neurexin 2)

2014-11-01  

Identity

HGNC
NRXN2
LOCATION
11q13.1
LOCUSID
9379
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9379
MIM: 600566
HGNC: 8009
Ensembl: ENSG00000110076

Variants:

dbSNP: 9379
ClinVar: 9379
TCGA: ENSG00000110076
COSMIC: NRXN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110076ENST00000265459Q9P2S2
ENSG00000110076ENST00000301894P58401
ENSG00000110076ENST00000377559Q9P2S2
ENSG00000110076ENST00000409571G5E9G7
ENSG00000110076ENST00000417749H7C3D6
ENSG00000110076ENST00000423049H7C2R8
ENSG00000110076ENST00000437746H7C3J4
ENSG00000110076ENST00000442300H7BZC7

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Neuronal SystemREACTOMER-HSA-112316
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

References

Pubmed IDYearTitleCitations
362426552022Neurexin 2 p.G849D variant, implicated in Parkinson's disease, increases reactive oxygen species, and reduces cell viability and mitochondrial membrane potential in SH-SY5Y cells.1
362426552022Neurexin 2 p.G849D variant, implicated in Parkinson's disease, increases reactive oxygen species, and reduces cell viability and mitochondrial membrane potential in SH-SY5Y cells.1
341269332021A genetic interaction of NRXN2 with GABRE, SYT1 and CASK in migraine patients: a case-control study.4
347775682021NRXN2 Possesses a Tumor Suppressor Potential via Inhibiting the Growth of Thyroid Cancer Cells.0
341269332021A genetic interaction of NRXN2 with GABRE, SYT1 and CASK in migraine patients: a case-control study.4
347775682021NRXN2 Possesses a Tumor Suppressor Potential via Inhibiting the Growth of Thyroid Cancer Cells.0
320990332020Translational Inhibition of α-Neurexin 2.6
320990332020Translational Inhibition of α-Neurexin 2.6
307098772019Mutations in NRXN1 and NRXN2 in a patient with early-onset epileptic encephalopathy and respiratory depression.11
307098772019Mutations in NRXN1 and NRXN2 in a patient with early-onset epileptic encephalopathy and respiratory depression.11
290450402018Neurexin gene family variants as risk factors for autism spectrum disorder.31
296549042018A de novo 921 Kb microdeletion at 11q13.1 including neurexin 2 in a boy with developmental delay, deficits in speech and language without autistic behaviors.2
290450402018Neurexin gene family variants as risk factors for autism spectrum disorder.31
296549042018A de novo 921 Kb microdeletion at 11q13.1 including neurexin 2 in a boy with developmental delay, deficits in speech and language without autistic behaviors.2
280132312017Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.24

Citation

Dessen P

NRXN2 (neurexin 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70978