NXN (nucleoredoxin)

2014-11-01  

Identity

HGNC
NXN
LOCATION
17p13.3
LOCUSID
64359
ALIAS
NRX,RRS2,TRG-4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64359
MIM: 612895
HGNC: 18008
Ensembl: ENSG00000167693

Variants:

dbSNP: 64359
ClinVar: 64359
TCGA: ENSG00000167693
COSMIC: NXN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167693ENST00000336868Q6DKJ4
ENSG00000167693ENST00000537628A0A0C4DGI2
ENSG00000167693ENST00000571684I3L4V6
ENSG00000167693ENST00000575801Q6DKJ4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
354066332022NXN Gene Epigenetic Changes in an Adult Neurogenesis Model of Alzheimer's Disease.3
359272362022NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3.2
354066332022NXN Gene Epigenetic Changes in an Adult Neurogenesis Model of Alzheimer's Disease.3
359272362022NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3.2
330484442021Novel pathogenic genomic variants leading to autosomal dominant and recessive Robinow syndrome.13
330484442021Novel pathogenic genomic variants leading to autosomal dominant and recessive Robinow syndrome.13
212519122011An interaction between human Sec63 and nucleoredoxin may provide the missing link between the SEC63 gene and polycystic liver disease.11
212519122011An interaction between human Sec63 and nucleoredoxin may provide the missing link between the SEC63 gene and polycystic liver disease.11
193080212009Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.34
193080212009Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.34
175672402007Nucleoredoxin, a novel thioredoxin family member involved in cell growth and differentiation.43
175672402007Nucleoredoxin, a novel thioredoxin family member involved in cell growth and differentiation.43

Citation

Dessen P

NXN (nucleoredoxin)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71064