OPN3 (opsin 3)

2014-11-01 Affiliation

Identity

HGNC

OPN3

LOCATION

1q43

LOCUSID

23596

ALIAS

ECPN,PPP1R116

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23596
MIM: 606695
HGNC: 14007
Ensembl: ENSG00000054277

Variants:

dbSNP: 23596
ClinVar: 23596
TCGA: ENSG00000054277
COSMIC: OPN3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000054277	ENST00000366554	Q9H1Y3
ENSG00000054277	ENST00000469376	Q6P5W7
ENSG00000054277	ENST00000478849	A0A1B0GUF8
ENSG00000054277	ENST00000490673	Q6GMT1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Opsins	REACTOME	R-HSA-419771
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38284195	2024	In vitro differentiation of human amniotic epithelial stem cells into keratinocytes regulated by OPN3.	0
38284195	2024	In vitro differentiation of human amniotic epithelial stem cells into keratinocytes regulated by OPN3.	0
36869204	2023	Opsin 3 mediates UVA-induced keratinocyte supranuclear melanin cap formation.	4
37823488	2023	Opsin 3 expression in human Langerhans cell histiocytosis and its mediation of ELD-1 cellular function.	0
36869204	2023	Opsin 3 mediates UVA-induced keratinocyte supranuclear melanin cap formation.	4
37823488	2023	Opsin 3 expression in human Langerhans cell histiocytosis and its mediation of ELD-1 cellular function.	0
35577105	2022	OPN3 Regulates Melanogenesis in Human Congenital Melanocytic Nevus Cells through Functional Interaction with BRAF(V600E).	1
36017595	2022	The effects of missense OPN3 mutations in melanocytic lesions on protein structure and light-sensitive function.	0
35577105	2022	OPN3 Regulates Melanogenesis in Human Congenital Melanocytic Nevus Cells through Functional Interaction with BRAF(V600E).	1
36017595	2022	The effects of missense OPN3 mutations in melanocytic lesions on protein structure and light-sensitive function.	0
33611338	2021	Identification of OPN3 as associated with non-syndromic oligodontia in a Japanese population.	3
33955704	2021	Expression of OPN3 in acral lentiginous melanoma and its associated with clinicohistopathologic features and prognosis.	7
34029574	2021	TGFβ2 Upregulates Tyrosinase Activity through Opsin-3 in Human Skin Melanocytes In Vitro.	6
33611338	2021	Identification of OPN3 as associated with non-syndromic oligodontia in a Japanese population.	3
33955704	2021	Expression of OPN3 in acral lentiginous melanoma and its associated with clinicohistopathologic features and prognosis.	7

Citation

Dessen P

OPN3 (opsin 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71134