OSCAR (osteoclast associated Ig-like receptor)

2014-11-01  

Identity

HGNC
OSCAR
LOCATION
19q13.42
LOCUSID
126014
ALIAS
PIGR3,PIgR-3

Other Information

Locus ID:

NCBI: 126014
MIM: 606862
HGNC: 29960
Ensembl: ENSG00000170909

Variants:

dbSNP: 126014
ClinVar: 126014
TCGA: ENSG00000170909
COSMIC: OSCAR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170909ENST00000284648Q8IYS5
ENSG00000170909ENST00000351806A0A0A0MR14
ENSG00000170909ENST00000356532A0A087X1R2
ENSG00000170909ENST00000358375A0A0A0MRF2
ENSG00000170909ENST00000359649A0A087WV17
ENSG00000170909ENST00000391760A8MWV3
ENSG00000170909ENST00000391761Q8IYS5
ENSG00000170909ENST00000611261A0A087WV17
ENSG00000170909ENST00000616215Q8IYS5
ENSG00000170909ENST00000616447A0A087X0P3
ENSG00000170909ENST00000617140A0A087X1R2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
322464882020Sex-biased ceRNA networks reveal that OSCAR can promote proliferation and migration of lung adenocarcinoma in women.2
328599402020Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.38
322464882020Sex-biased ceRNA networks reveal that OSCAR can promote proliferation and migration of lung adenocarcinoma in women.2
328599402020Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.38
285553642017Osteoclast-Associated Receptor (OSCAR) Distribution in the Synovial Tissues of Patients with Active RA and TNF-α and RANKL Regulation of Expression by Osteoclasts In Vitro.4
285553642017Osteoclast-Associated Receptor (OSCAR) Distribution in the Synovial Tissues of Patients with Active RA and TNF-α and RANKL Regulation of Expression by Osteoclasts In Vitro.4
265526972016Structural basis for collagen recognition by the immune receptor OSCAR.27
267867022016OSCAR-collagen signaling in monocytes plays a proinflammatory role and may contribute to the pathogenesis of rheumatoid arthritis.12
265526972016Structural basis for collagen recognition by the immune receptor OSCAR.27
267867022016OSCAR-collagen signaling in monocytes plays a proinflammatory role and may contribute to the pathogenesis of rheumatoid arthritis.12
257169982015OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes.29
257169982015OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes.29
244483482014Levels of soluble osteoclast-associated receptor (sOSCAR) in rheumatoid arthritis: link to disease severity and cardiovascular risk.7
244483482014Levels of soluble osteoclast-associated receptor (sOSCAR) in rheumatoid arthritis: link to disease severity and cardiovascular risk.7
229493492013The effect of rotative stress on CAII, FAS, FASL, OSCAR, and TRAP gene expression in osteoclasts.0

Citation

Dessen P

OSCAR (osteoclast associated Ig-like receptor)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71557