PAN2 (poly(A) specific ribonuclease subunit PAN2)

2014-11-01  

Identity

HGNC
PAN2
LOCATION
12q13.3
LOCUSID
9924
ALIAS
USP52
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9924
MIM: 617447
HGNC: 20074
Ensembl: ENSG00000135473

Variants:

dbSNP: 9924
ClinVar: 9924
TCGA: ENSG00000135473
COSMIC: PAN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135473ENST00000257931Q504Q3
ENSG00000135473ENST00000425394Q504Q3
ENSG00000135473ENST00000440411Q504Q3
ENSG00000135473ENST00000547572F8VXK8
ENSG00000135473ENST00000548043Q504Q3
ENSG00000135473ENST00000610546Q504Q3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947

References

Pubmed IDYearTitleCitations
353046022022Biallelic PAN2 variants in individuals with a syndromic neurodevelopmental disorder and multiple congenital anomalies.3
353046022022Biallelic PAN2 variants in individuals with a syndromic neurodevelopmental disorder and multiple congenital anomalies.3
345331982021USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer.2
345331982021USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer.2
330977102020USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP.14
330977102020USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP.14
295994862018USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization.20
295994862018USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization.20
233984562013The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.34
233984562013The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.34
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
145836022004Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein.53

Citation

Dessen P

PAN2 (poly(A) specific ribonuclease subunit PAN2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71644/js/haematological-explorer/