PDE8A (phosphodiesterase 8A)

2014-11-01  

Identity

HGNC
PDE8A
LOCATION
15q25.3
LOCUSID
5151
ALIAS
HsT19550
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5151
MIM: 602972
HGNC: 8793
Ensembl: ENSG00000073417

Variants:

dbSNP: 5151
ClinVar: 5151
TCGA: ENSG00000073417
COSMIC: PDE8A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073417ENST00000310298O60658
ENSG00000073417ENST00000339708O60658
ENSG00000073417ENST00000394553O60658
ENSG00000073417ENST00000478717O60658
ENSG00000073417ENST00000485596E9PIJ0
ENSG00000073417ENST00000557957O60658
ENSG00000073417ENST00000559086H0YNP3
ENSG00000073417ENST00000559742H0YKR1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
38325743202414-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway.0
385060472024AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.0
38325743202414-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway.0
385060472024AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.0
362777282022cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.1
362777282022cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.1
339315912021Phosphodiesterase 8A to discriminate in blood samples depressed patients and suicide attempters from healthy controls based on A-to-I RNA editing modifications.3
349362852021Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells.3
339315912021Phosphodiesterase 8A to discriminate in blood samples depressed patients and suicide attempters from healthy controls based on A-to-I RNA editing modifications.3
349362852021Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells.3
307707872019Brain region-specific alterations of RNA editing in PDE8A mRNA in suicide decedents.12
307707872019Brain region-specific alterations of RNA editing in PDE8A mRNA in suicide decedents.12
292622642018PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β(2)-Adrenergic Receptors and Adenylyl Cyclase 6.26
292622642018PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β(2)-Adrenergic Receptors and Adenylyl Cyclase 6.26
275606982016Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape.44

Citation

Dessen P

PDE8A (phosphodiesterase 8A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71800/cancer-prone-explorer/css/lib/haematological-explorer/