PDE8A (phosphodiesterase 8A)

2014-11-01  

Identity

HGNC
LOCATION
15q25.3
LOCUSID
ALIAS
HsT19550
FUSION GENES

Other Information

Locus ID:

NCBI: 5151
MIM: 602972
HGNC: 8793
Ensembl: ENSG00000073417

Variants:

dbSNP: 5151
ClinVar: 5151
TCGA: ENSG00000073417
COSMIC: PDE8A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073417ENST00000310298O60658
ENSG00000073417ENST00000339708O60658
ENSG00000073417ENST00000394553O60658
ENSG00000073417ENST00000478717O60658
ENSG00000073417ENST00000485596E9PIJ0
ENSG00000073417ENST00000557957O60658
ENSG00000073417ENST00000559086H0YNP3
ENSG00000073417ENST00000559742H0YKR1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
38325743202414-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway.0
385060472024AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.0
38325743202414-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway.0
385060472024AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.0
362777282022cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.1
362777282022cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.1
339315912021Phosphodiesterase 8A to discriminate in blood samples depressed patients and suicide attempters from healthy controls based on A-to-I RNA editing modifications.3
349362852021Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells.3
339315912021Phosphodiesterase 8A to discriminate in blood samples depressed patients and suicide attempters from healthy controls based on A-to-I RNA editing modifications.3
349362852021Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells.3
307707872019Brain region-specific alterations of RNA editing in PDE8A mRNA in suicide decedents.12
307707872019Brain region-specific alterations of RNA editing in PDE8A mRNA in suicide decedents.12
292622642018PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β(2)-Adrenergic Receptors and Adenylyl Cyclase 6.26
292622642018PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β(2)-Adrenergic Receptors and Adenylyl Cyclase 6.26
275606982016Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape.44

Citation

Dessen P

PDE8A (phosphodiesterase 8A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71800/cancer-prone-explorer/css/lib/js/web-card-_common.js