PIEZO2 (piezo type mechanosensitive ion channel component 2)

2014-11-01  

Identity

HGNC
PIEZO2
LOCATION
18p11.22
LOCUSID
63895
ALIAS
C18orf30,C18orf58,DA3,DA5,DAIPT,FAM38B,FAM38B2,HsT748,HsT771,MWKS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 63895
MIM: 613629
HGNC: 26270
Ensembl: ENSG00000154864

Variants:

dbSNP: 63895
ClinVar: 63895
TCGA: ENSG00000154864
COSMIC: PIEZO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154864ENST00000302079Q9H5I5
ENSG00000154864ENST00000383408E7EVM7
ENSG00000154864ENST00000503781Q9H5I5
ENSG00000154864ENST00000579112J3QLJ9
ENSG00000154864ENST00000579949V9GZ18
ENSG00000154864ENST00000580640Q9H5I5
ENSG00000154864ENST00000581680A0A2R8YG64
ENSG00000154864ENST00000582913J3KRQ5
ENSG00000154864ENST00000582937J3KRW1
ENSG00000154864ENST00000643712A0A2R8Y3N5

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378404812024Asymmetric expression of PIEZO2 in paraspinal muscles of adolescent idiopathic scoliosis.0
379751622024Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.2
382165742024PIEZO2 expression is an independent biomarker prognostic for gastric cancer and represents a potential therapeutic target.0
385688072024TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction.0
378404812024Asymmetric expression of PIEZO2 in paraspinal muscles of adolescent idiopathic scoliosis.0
379751622024Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.2
382165742024PIEZO2 expression is an independent biomarker prognostic for gastric cancer and represents a potential therapeutic target.0
385688072024TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction.0
367171012023The role of PIEZO ion channels in the musculoskeletal system.9
367533732023PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.3
371204272023Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis.13
371469702023PKA mediates modality-specific modulation of the mechanically gated ion channel PIEZO2.1
375411962023PIEZO2 in somatosensory neurons controls gastrointestinal transit.14
376163692023PIEZO2 and perineal mechanosensation are essential for sexual function.7
378951342023Disrupted Neural Regeneration in Dry Eye Secondary to Ankylosing Spondylitis-With a Theoretical Link between Piezo2 Channelopathy and Gateway Reflex, WDR Neurons, and Flare-Ups.1

Citation

Dessen P

PIEZO2 (piezo type mechanosensitive ion channel component 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71906