PLA2G4D (phospholipase A2 group IVD)

2014-11-01 Affiliation

Identity

HGNC

PLA2G4D

LOCATION

15q15.1

LOCUSID

283748

ALIAS

cPLA2delta

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 283748
MIM: 612864
HGNC: 30038
Ensembl: ENSG00000159337

Variants:

dbSNP: 283748
ClinVar: 283748
TCGA: ENSG00000159337
COSMIC: PLA2G4D

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000159337	ENST00000290472	Q86XP0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycerophospholipid metabolism	KEGG	ko00564
Ether lipid metabolism	KEGG	ko00565
Arachidonic acid metabolism	KEGG	ko00590
Linoleic acid metabolism	KEGG	ko00591
alpha-Linolenic acid metabolism	KEGG	ko00592
MAPK signaling pathway	KEGG	ko04010
VEGF signaling pathway	KEGG	ko04370
Fc epsilon RI signaling pathway	KEGG	ko04664
Long-term depression	KEGG	ko04730
GnRH signaling pathway	KEGG	ko04912
Glycerophospholipid metabolism	KEGG	hsa00564
Ether lipid metabolism	KEGG	hsa00565
Arachidonic acid metabolism	KEGG	hsa00590
Linoleic acid metabolism	KEGG	hsa00591
alpha-Linolenic acid metabolism	KEGG	hsa00592
MAPK signaling pathway	KEGG	hsa04010
VEGF signaling pathway	KEGG	hsa04370
Fc epsilon RI signaling pathway	KEGG	hsa04664
Long-term depression	KEGG	hsa04730
GnRH signaling pathway	KEGG	hsa04912
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Fc gamma R-mediated phagocytosis	KEGG	ko04666
Fc gamma R-mediated phagocytosis	KEGG	hsa04666
Metabolic pathways	KEGG	hsa01100
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Serotonergic synapse	KEGG	hsa04726
Ovarian steroidogenesis	KEGG	hsa04913
Ovarian steroidogenesis	KEGG	ko04913
Ras signaling pathway	KEGG	hsa04014
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Platelet activation	KEGG	hsa04611
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
Choline metabolism in cancer	KEGG	hsa05231
Choline metabolism in cancer	KEGG	ko05231
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
Glycerophospholipid biosynthesis	REACTOME	R-HSA-1483206
Synthesis of PA	REACTOME	R-HSA-1483166
Acyl chain remodelling of PE	REACTOME	R-HSA-1482839
Acyl chain remodelling of PC	REACTOME	R-HSA-1482788
Hydrolysis of LPC	REACTOME	R-HSA-1483115
Acyl chain remodelling of PS	REACTOME	R-HSA-1482801
Acyl chain remodelling of PI	REACTOME	R-HSA-1482922
Acyl chain remodelling of PG	REACTOME	R-HSA-1482925
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072

References

Pubmed ID	Year	Title	Citations
28440406	2017	Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population.	4
28440406	2017	Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population.	4
27670592	2016	Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.	118
27670592	2016	Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.	118
24349473	2013	Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.	35
24349473	2013	Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.	35
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	105
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	105
18686860	2008	[Study on the genetic association between the polymorphism of cytosolic phospholipase A2 family genes and schizophrenia].	1
18686860	2008	[Study on the genetic association between the polymorphism of cytosolic phospholipase A2 family genes and schizophrenia].	1
16213696	2005	A family based study of the genetic association between the PLA2G4D gene and schizophrenia.	1
16213696	2005	A family based study of the genetic association between the PLA2G4D gene and schizophrenia.	1
14709560	2004	Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin.	26

Citation

Dessen P

PLA2G4D (phospholipase A2 group IVD)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71955