POLR3E (RNA polymerase III subunit E)

2014-11-01 Affiliation

Identity

HGNC

POLR3E

LOCATION

16p12.2

LOCUSID

55718

ALIAS

C37,RPC5,SIN

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55718
MIM: 617815
HGNC: 30347
Ensembl: ENSG00000058600

Variants:

dbSNP: 55718
ClinVar: 55718
TCGA: ENSG00000058600
COSMIC: POLR3E

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000058600	ENST00000299853	Q9NVU0
ENSG00000058600	ENST00000359210	Q9NVU0
ENSG00000058600	ENST00000418581	Q9NVU0
ENSG00000058600	ENST00000561494	H3BSM3
ENSG00000058600	ENST00000563024	H3BRY1
ENSG00000058600	ENST00000564209	Q9NVU0
ENSG00000058600	ENST00000564750	H3BS41
ENSG00000058600	ENST00000564883	H3BSI5
ENSG00000058600	ENST00000565358	H3BMR4
ENSG00000058600	ENST00000565551	H3BM46
ENSG00000058600	ENST00000569757	H3BNJ0
ENSG00000058600	ENST00000615879	A0A0C4DH01

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Purine metabolism	KEGG	ko00230
Pyrimidine metabolism	KEGG	ko00240
RNA polymerase	KEGG	ko03020
Purine metabolism	KEGG	hsa00230
Pyrimidine metabolism	KEGG	hsa00240
RNA polymerase	KEGG	hsa03020
Cytosolic DNA-sensing pathway	KEGG	ko04623
Cytosolic DNA-sensing pathway	KEGG	hsa04623
RNA polymerase III, eukaryotes	KEGG	hsa_M00181
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
RNA polymerase III, eukaryotes	KEGG	M00181
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Cytosolic sensors of pathogen-associated DNA	REACTOME	R-HSA-1834949
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	REACTOME	R-HSA-504046
RNA Polymerase III Transcription	REACTOME	R-HSA-74158
RNA Polymerase III Abortive And Retractive Initiation	REACTOME	R-HSA-749476
RNA Polymerase III Transcription Initiation	REACTOME	R-HSA-76046
RNA Polymerase III Transcription Initiation From Type 1 Promoter	REACTOME	R-HSA-76061
RNA Polymerase III Transcription Initiation From Type 2 Promoter	REACTOME	R-HSA-76066
RNA Polymerase III Transcription Initiation From Type 3 Promoter	REACTOME	R-HSA-76071
RNA Polymerase III Chain Elongation	REACTOME	R-HSA-73780
RNA Polymerase III Transcription Termination	REACTOME	R-HSA-73980

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
32843346	2020	A mutation in POLR3E impairs antiviral immune response and RNA polymerase III.	12
32843346	2020	A mutation in POLR3E impairs antiviral immune response and RNA polymerase III.	12
29728610	2019	Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection.	36
29728610	2019	Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection.	36
12391170	2002	Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.	38
12391170	2002	Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.	38

Citation

Dessen P

POLR3E (RNA polymerase III subunit E)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72057