RLN3 (relaxin 3)

2014-11-01  

Identity

HGNC
RLN3
LOCATION
19p13.12
LOCUSID
117579
ALIAS
H3,RXN3,ZINS4,insl7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 117579
MIM: 606855
HGNC: 17135
Ensembl: ENSG00000171136

Variants:

dbSNP: 117579
ClinVar: 117579
TCGA: ENSG00000171136
COSMIC: RLN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171136ENST00000431365Q8WXF3
ENSG00000171136ENST00000585987K7ENX1

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Relaxin receptorsREACTOMER-HSA-444821
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
379670732023Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach.0
379670732023Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach.0
345372632021The putative role of the relaxin-3/RXFP3 system in clinical depression and anxiety: A systematic literature review.3
345372632021The putative role of the relaxin-3/RXFP3 system in clinical depression and anxiety: A systematic literature review.3
287861262018Serum relaxin-3 hormone relationship to male delayed puberty.3
287861262018Serum relaxin-3 hormone relationship to male delayed puberty.3
274882612017Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload.6
278882812017The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.5
274882612017Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload.6
278882812017The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.5
271932322016Identification of hydrophobic interactions between relaxin-3 and its receptor RXFP3: implication for a conformational change in the B-chain C-terminus during receptor binding.10
273532812016A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.1
274980382016Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.7
271932322016Identification of hydrophobic interactions between relaxin-3 and its receptor RXFP3: implication for a conformational change in the B-chain C-terminus during receptor binding.10
273532812016A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.1

Citation

Dessen P

RLN3 (relaxin 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72655