RNF114 (ring finger protein 114)

2014-11-01  

Identity

HGNC
RNF114
LOCATION
20q13.13
LOCUSID
55905
ALIAS
PSORS12,ZNF313
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55905
MIM: 612451
HGNC: 13094
Ensembl: ENSG00000124226

Variants:

dbSNP: 55905
ClinVar: 55905
TCGA: ENSG00000124226
COSMIC: RNF114

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124226ENST00000244061Q9Y508
ENSG00000124226ENST00000622920A0A096LP02
ENSG00000124226ENST00000622999A0A096LNT1
ENSG00000124226ENST00000623528A0A096LNN8
ENSG00000124226ENST00000623732A0A096LPF9
ENSG00000124226ENST00000625177A0A096LNV3

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375238042023RNF114 facilitates the proliferation, stemness, and metastasis of colorectal cancer.0
375238042023RNF114 facilitates the proliferation, stemness, and metastasis of colorectal cancer.0
355452022022E3 ubiquitin ligase RNF114 promotes vesicular stomatitis virus replication via inhibiting type I interferon production.3
355452022022E3 ubiquitin ligase RNF114 promotes vesicular stomatitis virus replication via inhibiting type I interferon production.3
246313322014Identification of RNF114 as a novel positive regulatory protein for T cell activation.7
251658852014The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation.26
253130372014XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.37
246313322014Identification of RNF114 as a novel positive regulatory protein for T cell activation.7
251658852014The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation.26
253130372014XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.37
236175962013Genetic variants of the genes encoding zinc finger protein 313 and interleukin-13 confer a risk for psoriasis in a Chinese Uygur population.1
236452062013ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).30
236175962013Genetic variants of the genes encoding zinc finger protein 313 and interleukin-13 confer a risk for psoriasis in a Chinese Uygur population.1
236452062013ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).30
222053042012Identification of rare, disease-associated variants in the promoter region of the RNF114 psoriasis susceptibility gene.1

Citation

Dessen P

RNF114 (ring finger protein 114)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72684