RTCB (RNA 2,3-cyclic phosphate and 5-OH ligase)

2014-11-01  

Identity

HGNC
RTCB
LOCATION
22q12.3
LOCUSID
51493
ALIAS
C22orf28,DJ149A16.6,FAAP,HSPC117
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51493
MIM: 613901
HGNC: 26935
Ensembl: ENSG00000100220

Variants:

dbSNP: 51493
ClinVar: 51493
TCGA: ENSG00000100220
COSMIC: RTCB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100220ENST00000216038Q9Y3I0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA processing in the nucleusREACTOMER-HSA-6784531

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384931482024Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease.0
384931482024Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease.0
375561112023The RNA-Splicing Ligase RTCB Promotes Influenza A Virus Replication by Suppressing Innate Immunity via Interaction with RNA Helicase DDX1.0
375561112023The RNA-Splicing Ligase RTCB Promotes Influenza A Virus Replication by Suppressing Innate Immunity via Interaction with RNA Helicase DDX1.0
348543792021Molecular architecture of the human tRNA ligase complex.15
348543792021Molecular architecture of the human tRNA ligase complex.15
287073202017Homology model of the human tRNA splicing ligase RtcB.10
287073202017Homology model of the human tRNA splicing ligase RtcB.10
246082642014hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.33
249412542014HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells.2
253784782014The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.102
246082642014hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.33
249412542014HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells.2
253784782014The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.102
213110212011HSPC117 is the essential subunit of a human tRNA splicing ligase complex.146

Citation

Dessen P

RTCB (RNA 2,3-cyclic phosphate and 5-OH ligase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72922/case-report-explorer/meetings/js/web-card-_common.js