SAR1A (secretion associated Ras related GTPase 1A)

2014-11-01  

Identity

HGNC
SAR1A
LOCATION
10q22.1
LOCUSID
56681
ALIAS
SAR1,SARA1,Sara,masra2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56681
MIM: 607691
HGNC: 10534
Ensembl: ENSG00000079332

Variants:

dbSNP: 56681
ClinVar: 56681
TCGA: ENSG00000079332
COSMIC: SAR1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000079332ENST00000373236Q5SQT8
ENSG00000079332ENST00000373238Q9NR31
ENSG00000079332ENST00000373238Q5SQT9
ENSG00000079332ENST00000373239X1WI22
ENSG00000079332ENST00000373241Q9NR31
ENSG00000079332ENST00000373241Q5SQT9
ENSG00000079332ENST00000373242Q9NR31
ENSG00000079332ENST00000373242Q5SQT9
ENSG00000079332ENST00000431664Q9NR31
ENSG00000079332ENST00000431664Q5SQT9
ENSG00000079332ENST00000452767H0Y5E8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
COPII complexKEGGhsa_M00404
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
COPII complexKEGGM00404

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386877992024Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.1
386877992024Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.1
360479712022SAR1A regulates the RhoA/YAP and autophagy signaling pathways to influence osteosarcoma invasion and metastasis.5
360479712022SAR1A regulates the RhoA/YAP and autophagy signaling pathways to influence osteosarcoma invasion and metastasis.5
323580662020Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly.13
323580662020Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly.13
304851592019Fatty-acid binding protein 5 modulates the SAR1 GTPase cycle and enhances budding of large COPII cargoes.9
304851592019Fatty-acid binding protein 5 modulates the SAR1 GTPase cycle and enhances budding of large COPII cargoes.9
297185412018Differential cell surface recruitment of the superoxide-producing NADPH oxidases Nox1, Nox2 and Nox5: The role of the small GTPase Sar1.5
300786782018Pull down assay for GTP-bound form of Sar1a reveals its activation during morphological differentiation.5
302516872018Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Na(v)1.5.10
297185412018Differential cell surface recruitment of the superoxide-producing NADPH oxidases Nox1, Nox2 and Nox5: The role of the small GTPase Sar1.5
300786782018Pull down assay for GTP-bound form of Sar1a reveals its activation during morphological differentiation.5
302516872018Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Na(v)1.5.10
284993942017SAR1a promoter polymorphisms are not associated with fetal hemoglobin in patients with sickle cell disease from Cameroon.2

Citation

Dessen P

SAR1A (secretion associated Ras related GTPase 1A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72979/js/gene-fusions/?id=72979