SDE2 (SDE2 telomere maintenance homolog)

2014-11-01  

Identity

HGNC
SDE2
LOCATION
1q42.12
LOCUSID
163859
ALIAS
C1orf55,dJ671D7.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 163859
HGNC: 26643
Ensembl: ENSG00000143751

Variants:

dbSNP: 163859
ClinVar: 163859
TCGA: ENSG00000143751
COSMIC: SDE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143751ENST00000272091Q6IQ49

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
358503052022Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks.7
358503052022Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks.7
343655072021SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing.5
343655072021SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing.5
331279072020SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks.25
331279072020SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks.25
306987502019Conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks.14
306987502019Conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks.14
279069592016PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress.19
279069592016PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress.19

Citation

Dessen P

SDE2 (SDE2 telomere maintenance homolog)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73066