SEC13 (SEC13 homolog, nuclear pore and COPII coat complex component)

2014-11-01  

Identity

HGNC
SEC13
LOCATION
3p25.3
LOCUSID
6396
ALIAS
D3S1231E,SEC13L1,SEC13R,npp-20
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6396
MIM: 600152
HGNC: 10697
Ensembl: ENSG00000157020

Variants:

dbSNP: 6396
ClinVar: 6396
TCGA: ENSG00000157020
COSMIC: SEC13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157020ENST00000337354P55735
ENSG00000157020ENST00000350697P55735
ENSG00000157020ENST00000383801P55735
ENSG00000157020ENST00000397109P55735
ENSG00000157020ENST00000397117A8MXL6
ENSG00000157020ENST00000428626C9J0S2
ENSG00000157020ENST00000431352E7ERC8
ENSG00000157020ENST00000432213C9JIB6
ENSG00000157020ENST00000445064C9JBJ5

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
mTOR signaling pathwayKEGGhsa04150
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
RNA transportKEGGko03013
RNA transportKEGGhsa03013
COPII complexKEGGhsa_M00404
Nuclear pore complexKEGGhsa_M00427
COPII complexKEGGM00404
Nuclear pore complexKEGGM00427
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen Presentation: Folding, assembly and peptide loading of class I MHCREACTOMER-HSA-983170
MHC class II antigen presentationREACTOMER-HSA-2132295
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
299487822018Sec13 is a positive regulator of VISA-mediated antiviral signaling.8
299487822018Sec13 is a positive regulator of VISA-mediated antiviral signaling.8
282402212017Mammalian TRAPPIII Complex positively modulates the recruitment of Sec13/31 onto COPII vesicles.18
282402212017Mammalian TRAPPIII Complex positively modulates the recruitment of Sec13/31 onto COPII vesicles.18
254525882015Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals.19
254525882015Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals.19
223313542012Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion.14
223313542012Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion.14
196829732009The coat protein complex II, COPII, protein Sec13 directly interacts with presenilin-1.4
196829732009The coat protein complex II, COPII, protein Sec13 directly interacts with presenilin-1.4
187138352008Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development.93
187138352008Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development.93
181600402007Architecture of a coat for the nuclear pore membrane.83
181600402007Architecture of a coat for the nuclear pore membrane.83
164079552006Structure of the Sec13/31 COPII coat cage.149

Citation

Dessen P

SEC13 (SEC13 homolog, nuclear pore and COPII coat complex component)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73079