SLC13A3 (solute carrier family 13 member 3)

2014-11-01  

Identity

HGNC
SLC13A3
LOCATION
20q13.12
LOCUSID
64849
ALIAS
ARLIAK,NADC3,SDCT2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64849
MIM: 606411
HGNC: 14430
Ensembl: ENSG00000158296

Variants:

dbSNP: 64849
ClinVar: 64849
TCGA: ENSG00000158296
COSMIC: SLC13A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158296ENST00000279027Q8WWT9
ENSG00000158296ENST00000290317Q8WWT9
ENSG00000158296ENST00000372121A0A0A0MRQ6
ENSG00000158296ENST00000413164Q8WWT9
ENSG00000158296ENST00000417157C9J4A3
ENSG00000158296ENST00000420568X6RDV4
ENSG00000158296ENST00000450298H7C0C8
ENSG00000158296ENST00000468915C9J7L4
ENSG00000158296ENST00000472148Q8WWT9
ENSG00000158296ENST00000495082Q8WWT9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Sodium-coupled sulphate, di- and tri-carboxylate transportersREACTOMER-HSA-433137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366960702023Association of Single Nucleotide Polymorphisms in KCNA10 and SLC13A3 Genes with the Susceptibility to Chronic Kidney Disease of Unknown Etiology in Central Indian Patients.2
377943282023Structural and functional implications of SLC13A3 and SLC9A6 mutations: an in silico approach to understanding intellectual disability.1
366960702023Association of Single Nucleotide Polymorphisms in KCNA10 and SLC13A3 Genes with the Susceptibility to Chronic Kidney Disease of Unknown Etiology in Central Indian Patients.2
377943282023Structural and functional implications of SLC13A3 and SLC9A6 mutations: an in silico approach to understanding intellectual disability.1
270536892016Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron.20
270536892016Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron.20
243518562014An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka.38
253549432014Transporters involved in renal excretion of N-carbamoylglutamate, an orphan drug to treat inborn n-acetylglutamate synthase deficiency.2
243518562014An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka.38
253549432014Transporters involved in renal excretion of N-carbamoylglutamate, an orphan drug to treat inborn n-acetylglutamate synthase deficiency.2
242471552013Glutathione is a low-affinity substrate of the human sodium-dependent dicarboxylate transporter.3
242471552013Glutathione is a low-affinity substrate of the human sodium-dependent dicarboxylate transporter.3
218652622011Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3.13
218736652011PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3.14
218652622011Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3.13

Citation

Dessen P

SLC13A3 (solute carrier family 13 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73279