SLC38A9 (solute carrier family 38 member 9)

2014-11-01  

Identity

HGNC
SLC38A9
LOCATION
5q11.2
LOCUSID
153129
ALIAS
URLC11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 153129
MIM: 616203
HGNC: 26907
Ensembl: ENSG00000177058

Variants:

dbSNP: 153129
ClinVar: 153129
TCGA: ENSG00000177058
COSMIC: SLC38A9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177058ENST00000318672Q8NBW4
ENSG00000177058ENST00000318672A0A024QZR9
ENSG00000177058ENST00000396865Q8NBW4
ENSG00000177058ENST00000396865A0A024QZR9
ENSG00000177058ENST00000416547B3KVK8
ENSG00000177058ENST00000502247D6RHW0
ENSG00000177058ENST00000503817D6RER8
ENSG00000177058ENST00000503891E7ESU6
ENSG00000177058ENST00000505563D6RBB9
ENSG00000177058ENST00000505708D6RHF5
ENSG00000177058ENST00000506624D6RDH2
ENSG00000177058ENST00000507109D6RDH2
ENSG00000177058ENST00000508124D6RE72
ENSG00000177058ENST00000511233D6R9Q7
ENSG00000177058ENST00000512208D6RG31
ENSG00000177058ENST00000512595Q8NBW4
ENSG00000177058ENST00000513275D6RIW7
ENSG00000177058ENST00000513993D6R9X0
ENSG00000177058ENST00000515629Q8NBW4

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
mTOR signaling pathwayKEGGhsa04150

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
328689262020Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.24
328689262020Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.24
301812602018Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.70
301812602018Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.70
290539702017mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.229
290539702017mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.229
255611752015SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.347
255679062015Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.432
259636552015Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.155
255611752015SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.347
255679062015Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.432
259636552015Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.155
247627462014New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acid.2
247627462014New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acid.2

Citation

Dessen P

SLC38A9 (solute carrier family 38 member 9)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73429/gene-fusions-explorer/js/css/template-card.css