SLC8B1 (solute carrier family 8 member B1)

2014-11-01  

Identity

HGNC
SLC8B1
LOCATION
12q24.13
LOCUSID
80024
ALIAS
NCKX6,NCLX,SLC24A6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80024
MIM: 609841
HGNC: 26175
Ensembl: ENSG00000089060

Variants:

dbSNP: 80024
ClinVar: 80024
TCGA: ENSG00000089060
COSMIC: SLC8B1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089060ENST00000202831Q6J4K2
ENSG00000089060ENST00000546737Q6J4K2
ENSG00000089060ENST00000548186F8VWW9
ENSG00000089060ENST00000549069F8VW44
ENSG00000089060ENST00000549181F8VR99
ENSG00000089060ENST00000549372F8VTU4
ENSG00000089060ENST00000549605F8W134
ENSG00000089060ENST00000550047A0A0B4J252
ENSG00000089060ENST00000550672H0YI75
ENSG00000089060ENST00000552014Q6J4K2
ENSG00000089060ENST00000552613F8W134

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium/Calcium exchangersREACTOMER-HSA-425561

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
349421492022Disrupted expression of mitochondrial NCLX sensitizes neuroglial networks to excitotoxic stimuli and renders synaptic activity toxic.6
358872962022Spatial and Functional Crosstalk between the Mitochondrial Na(+)-Ca(2+) Exchanger NCLX and the Sarcoplasmic Reticulum Ca(2+) Pump SERCA in Cardiomyocytes.5
365527542022CKII Control of Axonal Plasticity Is Mediated by Mitochondrial Ca(2+) via Mitochondrial NCLX.2
349421492022Disrupted expression of mitochondrial NCLX sensitizes neuroglial networks to excitotoxic stimuli and renders synaptic activity toxic.6
358872962022Spatial and Functional Crosstalk between the Mitochondrial Na(+)-Ca(2+) Exchanger NCLX and the Sarcoplasmic Reticulum Ca(2+) Pump SERCA in Cardiomyocytes.5
365527542022CKII Control of Axonal Plasticity Is Mediated by Mitochondrial Ca(2+) via Mitochondrial NCLX.2
340790532021Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation.20
349445202021Physiological and Pathophysiological Roles of Mitochondrial Na(+)-Ca(2+) Exchanger, NCLX, in Hearts.9
340790532021Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation.20
349445202021Physiological and Pathophysiological Roles of Mitochondrial Na(+)-Ca(2+) Exchanger, NCLX, in Hearts.9
329147522020Dichotomous role of the human mitochondrial Na(+)/Ca2(+)/Li(+) exchanger NCLX in colorectal cancer growth and metastasis.27
329147522020Dichotomous role of the human mitochondrial Na(+)/Ca2(+)/Li(+) exchanger NCLX in colorectal cancer growth and metastasis.27
306581532019Functional properties and mode of regulation of the mitochondrial Na(+)/Ca(2+) exchanger, NCLX.21
306581532019Functional properties and mode of regulation of the mitochondrial Na(+)/Ca(2+) exchanger, NCLX.21
305668702018Allosteric Regulation of NCLX by Mitochondrial Membrane Potential Links the Metabolic State and Ca(2+) Signaling in Mitochondria.32

Citation

Dessen P

SLC8B1 (solute carrier family 8 member B1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73494