SNRPB (small nuclear ribonucleoprotein polypeptides B and B1)

2014-11-01  

Identity

HGNC
SNRPB
LOCATION
20p13
LOCUSID
6628
ALIAS
CCMS,COD,SNRPB1,Sm-B/B,SmB/B,SmB/SmB,snRNP-B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6628
MIM: 182282
HGNC: 11153
Ensembl: ENSG00000125835

Variants:

dbSNP: 6628
ClinVar: 6628
TCGA: ENSG00000125835
COSMIC: SNRPB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125835ENST00000381342P14678
ENSG00000125835ENST00000381342Q66K91
ENSG00000125835ENST00000438552P14678
ENSG00000125835ENST00000474384S4R3P3

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Systemic lupus erythematosusKEGGko05322
Systemic lupus erythematosusKEGGhsa05322
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, U1-snRNPKEGGhsa_M00351
Spliceosome, U2-snRNPKEGGhsa_M00352
Spliceosome, 35S U5-snRNPKEGGhsa_M00355
Spliceosome, U4/U6.U5 tri-snRNPKEGGhsa_M00354
Sm core complexKEGGhsa_M00398
Spliceosome, U1-snRNPKEGGM00351
Spliceosome, U2-snRNPKEGGM00352
Spliceosome, U4/U6.U5 tri-snRNPKEGGM00354
Spliceosome, 35S U5-snRNPKEGGM00355
Sm core complexKEGGM00398
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA Splicing - Minor PathwayREACTOMER-HSA-72165
Processing of Capped Intronless Pre-mRNAREACTOMER-HSA-75067
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAsREACTOMER-HSA-77588
SLBP independent Processing of Histone Pre-mRNAsREACTOMER-HSA-111367
Metabolism of non-coding RNAREACTOMER-HSA-194441
snRNP AssemblyREACTOMER-HSA-191859

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381898792024SNRPB promotes the progression of hepatocellular carcinoma via regulating cell cycle, oxidative stress, and ferroptosis.0
381898792024SNRPB promotes the progression of hepatocellular carcinoma via regulating cell cycle, oxidative stress, and ferroptosis.0
373915932023The splicing factor SNRPB promotes ovarian cancer progression through regulating aberrant exon skipping of POLA1 and BRCA2.0
373915932023The splicing factor SNRPB promotes ovarian cancer progression through regulating aberrant exon skipping of POLA1 and BRCA2.0
349849762022Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation.14
351526712022[Regulatory effect of small nuclear ribonucleoprotein-associated protein B on proliferation and metastasis of liver cancer cells].1
349849762022Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation.14
351526712022[Regulatory effect of small nuclear ribonucleoprotein-associated protein B on proliferation and metastasis of liver cancer cells].1
319306372020c-Myc-mediated SNRPB upregulation functions as an oncogene in hepatocellular carcinoma.13
321063642020SNRPB promotes cervical cancer progression through repressing p53 expression.14
332897002020SNRPB-mediated RNA splicing drives tumor cell proliferation and stemness in hepatocellular carcinoma.18
319306372020c-Myc-mediated SNRPB upregulation functions as an oncogene in hepatocellular carcinoma.13
321063642020SNRPB promotes cervical cancer progression through repressing p53 expression.14
332897002020SNRPB-mediated RNA splicing drives tumor cell proliferation and stemness in hepatocellular carcinoma.18
315115022019SNRPB promotes the tumorigenic potential of NSCLC in part by regulating RAB26.28

Citation

Dessen P

SNRPB (small nuclear ribonucleoprotein polypeptides B and B1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74034