SORCS3 (sortilin related VPS10 domain containing receptor 3)

2014-11-01  

Identity

HGNC
LOCATION
10q25.1
LOCUSID
ALIAS
SORCS
FUSION GENES

Other Information

Locus ID:

NCBI: 22986
MIM: 606285
HGNC: 16699
Ensembl: ENSG00000156395

Variants:

dbSNP: 22986
ClinVar: 22986
TCGA: ENSG00000156395
COSMIC: SORCS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156395ENST00000369699Q9UPU3
ENSG00000156395ENST00000369701Q9UPU3
ENSG00000156395ENST00000393176Q5CAJ2

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

References

Pubmed IDYearTitleCitations
367029972023Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.101
368334092023Independent Associated SNPs at SORCS3 and Its Protein Interactors for Multiple Brain-Related Disorders and Traits.2
367029972023Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.101
368334092023Independent Associated SNPs at SORCS3 and Its Protein Interactors for Multiple Brain-Related Disorders and Traits.2
353934322022SorCS3 promotes the internalization of p75(NTR) to inhibit GBM progression.5
359401322022Cryo-EM structure studies of the human VPS10 domain-containing receptor SorCS3.1
353934322022SorCS3 promotes the internalization of p75(NTR) to inhibit GBM progression.5
359401322022Cryo-EM structure studies of the human VPS10 domain-containing receptor SorCS3.1
329666942021Non-coding variants in MYH11, FZD3, and SORCS3 are associated with dementia in women.15
329666942021Non-coding variants in MYH11, FZD3, and SORCS3 are associated with dementia in women.15
305865382018The SORCS3 gene is mutated in brothers with infantile spasms and intellectual disability.5
305865382018The SORCS3 gene is mutated in brothers with infantile spasms and intellectual disability.5
288271482017Hidden Twins: SorCS Neuroreceptors Form Stable Dimers.10
288271482017Hidden Twins: SorCS Neuroreceptors Form Stable Dimers.10
263628882016Genetic analysis of the isolated Faroe Islands reveals SORCS3 as a potential multiple sclerosis risk gene.3

Citation

Dessen P

SORCS3 (sortilin related VPS10 domain containing receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74073/cancer-prone-explorer/css/lib/meetings/