SPINK9 (serine peptidase inhibitor Kazal type 9)

2014-11-01  

Identity

HGNC
SPINK9
LOCATION
5q32
LOCUSID
643394
ALIAS
LEKTI2

Other Information

Locus ID:

NCBI: 643394
MIM: 613511
HGNC: 32951
Ensembl: ENSG00000204909

Variants:

dbSNP: 643394
ClinVar: 643394
TCGA: ENSG00000204909
COSMIC: SPINK9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204909ENST00000377906Q5DT21
ENSG00000204909ENST00000511717D6RJC5

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
244411022014SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation.6
244411022014SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation.6
225055192012Characterization of SPINK9, a KLK5-specific inhibitor expressed in palmo-plantar epidermis.1
225055192012Characterization of SPINK9, a KLK5-specific inhibitor expressed in palmo-plantar epidermis.1
218995982011Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2.3
218995982011Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2.3
191907732009Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor.10
191944792009SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor.14
191907732009Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor.10
191944792009SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor.14

Citation

Dessen P

SPINK9 (serine peptidase inhibitor Kazal type 9)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74186