SPRN (shadow of prion protein)

2014-11-01  

Identity

HGNC
SPRN
LOCATION
10q26.3
LOCUSID
503542
ALIAS
SHADOO,SHO,bA108K14.1

Other Information

Locus ID:

NCBI: 503542
MIM: 610447
HGNC: 16871
Ensembl: ENSG00000203772

Variants:

dbSNP: 503542
ClinVar: 503542
TCGA: ENSG00000203772
COSMIC: SPRN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000203772ENST00000414069Q5BIV9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

References

Pubmed IDYearTitleCitations
243904752014Disruption of glycosylation enhances ubiquitin-mediated proteasomal degradation of Shadoo in Scrapie-infected rodents and cultured cells.3
243904752014Disruption of glycosylation enhances ubiquitin-mediated proteasomal degradation of Shadoo in Scrapie-infected rodents and cultured cells.3
212577472011Conserved stress-protective activity between prion protein and Shadoo.19
212577472011Conserved stress-protective activity between prion protein and Shadoo.19
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
187782612008A novel solid phase technology for high-throughput gene synthesis.21
188058282008Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease.36
188058282008Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease.36
187782612008A novel solid phase technology for high-throughput gene synthesis.21
188058282008Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease.36

Citation

Dessen P

SPRN (shadow of prion protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74202