SRRM1 (serine and arginine repetitive matrix 1)

2014-11-01  

Identity

HGNC
SRRM1
LOCATION
1p36.11
LOCUSID
10250
ALIAS
160-KD,POP101,SRM160
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10250
MIM: 605975
HGNC: 16638
Ensembl: ENSG00000133226

Variants:

dbSNP: 10250
ClinVar: 10250
TCGA: ENSG00000133226
COSMIC: SRRM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133226ENST00000323848Q8IYB3
ENSG00000133226ENST00000323848A0A0S2Z4W1
ENSG00000133226ENST00000374389A9Z1X7
ENSG00000133226ENST00000447431E9PCT1
ENSG00000133226ENST00000593639M0QXG5
ENSG00000133226ENST00000596378M0R088
ENSG00000133226ENST00000600523M0R1E7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Exon junction complex (EJC)KEGGhsa_M00430
Exon junction complex (EJC)KEGGM00430
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
305907652019A cell-based splicing reporter system to identify regulators of cis-splicing between adjacent genes.12
305907652019A cell-based splicing reporter system to identify regulators of cis-splicing between adjacent genes.12
163547062006Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion.105
163547062006Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion.105
161598772005Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.13
161598772005Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.13
150240322004In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160.17
150240322004In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160.17
125817382003Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins.46
126241822003The spatial targeting and nuclear matrix binding domains of SRm160.33
125817382003Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins.46
126241822003The spatial targeting and nuclear matrix binding domains of SRm160.33
1199136020021H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR.2
1199136020021H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR.2

Citation

Dessen P

SRRM1 (serine and arginine repetitive matrix 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74243