ST6GAL2 (ST6 beta-galactoside alpha-2,6-sialyltransferase 2)

2014-11-01  

Identity

HGNC
ST6GAL2
LOCATION
2q12.3
LOCUSID
84620
ALIAS
SIAT2,ST6GalII
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84620
MIM: 608472
HGNC: 10861
Ensembl: ENSG00000144057

Variants:

dbSNP: 84620
ClinVar: 84620
TCGA: ENSG00000144057
COSMIC: ST6GAL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144057ENST00000361686Q96JF0
ENSG00000144057ENST00000361803H7BY52
ENSG00000144057ENST00000409087Q96JF0
ENSG00000144057ENST00000409382Q96JF0
ENSG00000144057ENST00000419159C9JIK2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
Other types of O-glycan biosynthesisKEGGko00514
N-Glycan biosynthesisKEGGhsa00510
Other types of O-glycan biosynthesisKEGGhsa00514
Metabolic pathwaysKEGGhsa01100
N-glycan biosynthesis, complex typeKEGGhsa_M00075
N-glycan biosynthesis, complex typeKEGGM00075
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Sialic acid metabolismREACTOMER-HSA-4085001

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
366469122023Role of ST6GAL1 and ST6GAL2 in subversion of cellular signaling during enteroaggregative Escherichia coli infection of human intestinal epithelial cell lines.2
366469122023Role of ST6GAL1 and ST6GAL2 in subversion of cellular signaling during enteroaggregative Escherichia coli infection of human intestinal epithelial cell lines.2
197685372010Transcriptional regulation of the human ST6GAL2 gene in cerebral cortex and neuronal cells.22
198502832010Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.34
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.14
197685372010Transcriptional regulation of the human ST6GAL2 gene in cerebral cortex and neuronal cells.22
198502832010Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.34
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.14
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.94
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.94
126033282003Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II.26
126033282003Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II.26

Citation

Dessen P

ST6GAL2 (ST6 beta-galactoside alpha-2,6-sialyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74270