TEAD2 (TEA domain transcription factor 2)

2014-11-01  

Identity

HGNC
TEAD2
LOCATION
19q13.33
LOCUSID
8463
ALIAS
ETF,TEAD-2,TEF-4,TEF4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8463
MIM: 601729
HGNC: 11715
Ensembl: ENSG00000074219

Variants:

dbSNP: 8463
ClinVar: 8463
TCGA: ENSG00000074219
COSMIC: TEAD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074219ENST00000311227Q15562
ENSG00000074219ENST00000377214Q15562
ENSG00000074219ENST00000377214A0A024QZE2
ENSG00000074219ENST00000539846Q15562
ENSG00000074219ENST00000593945Q15562
ENSG00000074219ENST00000596757M0R290
ENSG00000074219ENST00000598810Q15562
ENSG00000074219ENST00000598823M0R1A5
ENSG00000074219ENST00000601519Q15562
ENSG00000074219ENST00000601519A0A024QZE2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Hippo signalingKEGGhsa_M00683
Hippo signalingKEGGM00683
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expressionREACTOMER-HSA-2032785
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392

References

Pubmed IDYearTitleCitations
368940362023A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23.6
369075232023A TEAD2-Driven Endothelial-Like Program Shapes Basal-Like Differentiation and Metastasis of Pancreatic Cancer.2
368940362023A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23.6
369075232023A TEAD2-Driven Endothelial-Like Program Shapes Basal-Like Differentiation and Metastasis of Pancreatic Cancer.2
320873592020Conformational analysis of the riboflavin-responsive ETF:QO-p.Pro456Leu variant associated with mild multiple acyl-CoA dehydrogenase deficiency.6
323238242020TEAD2 as a novel prognostic factor for hepatocellular carcinoma.9
320873592020Conformational analysis of the riboflavin-responsive ETF:QO-p.Pro456Leu variant associated with mild multiple acyl-CoA dehydrogenase deficiency.6
323238242020TEAD2 as a novel prognostic factor for hepatocellular carcinoma.9
314856142019MicroRNA‑608 sensitizes non‑small cell lung cancer cells to cisplatin by targeting TEAD2.12
314856142019MicroRNA‑608 sensitizes non‑small cell lung cancer cells to cisplatin by targeting TEAD2.12
259954502015Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor.18
259954502015Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor.18
203684662010Structural and functional analysis of the YAP-binding domain of human TEAD2.81
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
203684662010Structural and functional analysis of the YAP-binding domain of human TEAD2.81

Citation

Dessen P

TEAD2 (TEA domain transcription factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74607