TMEM219 (transmembrane protein 219)

2014-11-01  

Identity

HGNC
TMEM219
LOCATION
16p11.2
LOCUSID
124446
ALIAS
IGFBP-3R
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 124446
HGNC: 25201
Ensembl: ENSG00000149932

Variants:

dbSNP: 124446
ClinVar: 124446
TCGA: ENSG00000149932
COSMIC: TMEM219

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149932ENST00000279396Q86XT9
ENSG00000149932ENST00000279396A0A024R618
ENSG00000149932ENST00000414689Q86XT9
ENSG00000149932ENST00000414689A0A024R618
ENSG00000149932ENST00000561899Q86XT9
ENSG00000149932ENST00000561899A0A024R618
ENSG00000149932ENST00000566848Q86XT9
ENSG00000149932ENST00000566848A0A024R618
ENSG00000149932ENST00000569445I3L4B3
ENSG00000149932ENST00000569481H3BML8
ENSG00000149932ENST00000570255Q86XT9
ENSG00000149932ENST00000570255A0A024R618
ENSG00000149932ENST00000575829I3L2J7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Death Receptors and LigandsREACTOMER-HSA-6803211

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383182982024TMEM219 regulates the transcription factor expression and proliferation of beta cells.0
383182982024TMEM219 regulates the transcription factor expression and proliferation of beta cells.0
351155612022The IGFBP3/TMEM219 pathway regulates beta cell homeostasis.12
351155612022The IGFBP3/TMEM219 pathway regulates beta cell homeostasis.12
276299212016IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses.58
276299212016IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses.58

Citation

Dessen P

TMEM219 (transmembrane protein 219)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74885