TREML2 (triggering receptor expressed on myeloid cells like 2)

2014-11-01  

Identity

HGNC
TREML2
LOCATION
6p21.1
LOCUSID
79865
ALIAS
C6orf76,TLT-2,TLT2,dJ238O23.1

Other Information

Locus ID:

NCBI: 79865
MIM: 609715
HGNC: 21092
Ensembl: ENSG00000112195

Variants:

dbSNP: 79865
ClinVar: 79865
TCGA: ENSG00000112195
COSMIC: TREML2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112195ENST00000483722Q5T2D2

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
379806752023Associations Between TREML2 Gene Variants and Alzheimer's Disease: Biomarkers, Neuroimage, and Cognition.0
379806752023Associations Between TREML2 Gene Variants and Alzheimer's Disease: Biomarkers, Neuroimage, and Cognition.0
364302482022TREML2 Gene Expression and Its Missense Variant rs3747742 Associate with White Matter Hyperintensity Volume and Alzheimer's Disease-Related Brain Atrophy in the General Population.0
364302482022TREML2 Gene Expression and Its Missense Variant rs3747742 Associate with White Matter Hyperintensity Volume and Alzheimer's Disease-Related Brain Atrophy in the General Population.0
320737392020A TREML2 missense variant influences specific hippocampal subfield volumes in cognitively normal elderly subjects.6
330421152020TLT2 Suppresses Th1 Response by Promoting IL-6 Production in Monocyte Through JAK/STAT3 Signal Pathway in Tuberculosis.5
320737392020A TREML2 missense variant influences specific hippocampal subfield volumes in cognitively normal elderly subjects.6
330421152020TLT2 Suppresses Th1 Response by Promoting IL-6 Production in Monocyte Through JAK/STAT3 Signal Pathway in Tuberculosis.5
303618462019Myeloid cell-like transcript 2 is related to liver inflammation and the pathogenesis of hepatitis B via the involvement of CD8(+)T cell activation.5
310445642019A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276.3
303618462019Myeloid cell-like transcript 2 is related to liver inflammation and the pathogenesis of hepatitis B via the involvement of CD8(+)T cell activation.5
310445642019A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276.3
297784232018Genetic variants of TREML2 are associated with HLA-B27-positive ankylosing spondylitis.3
297784232018Genetic variants of TREML2 are associated with HLA-B27-positive ankylosing spondylitis.3
267975172017A Missense Variant in TREML2 Reduces Risk of Alzheimer's Disease in a Han Chinese Population.6

Citation

Dessen P

TREML2 (triggering receptor expressed on myeloid cells like 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75133