UFM1 (ubiquitin fold modifier 1)

2014-11-01  

Identity

HGNC
UFM1
LOCATION
13q13.3
LOCUSID
51569
ALIAS
BM-002,C13orf20,HLD14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51569
MIM: 610553
HGNC: 20597
Ensembl: ENSG00000120686

Variants:

dbSNP: 51569
ClinVar: 51569
TCGA: ENSG00000120686
COSMIC: UFM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120686ENST00000239878P61960
ENSG00000120686ENST00000379649P61960
ENSG00000120686ENST00000437952H0Y614

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375950362023Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control.5
379801682023Inhibition of UFM1 expression suppresses cancer progression and is linked to the dismal prognosis and immune infiltration in oral squamous cell carcinoma.0
375950362023Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control.5
379801682023Inhibition of UFM1 expression suppresses cancer progression and is linked to the dismal prognosis and immune infiltration in oral squamous cell carcinoma.0
356803752022Modification of ERα by UFM1 Increases Its Stability and Transactivity for Breast Cancer Development.4
359264572022Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation.16
363441652022Emerging role of protein modification by UFM1 in cancer.4
365433792022Modification of PLAC8 by UFM1 affects tumorous proliferation and immune response by impacting PD-L1 levels in triple-negative breast cancer.6
356803752022Modification of ERα by UFM1 Increases Its Stability and Transactivity for Breast Cancer Development.4
359264572022Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation.16
363441652022Emerging role of protein modification by UFM1 in cancer.4
365433792022Modification of PLAC8 by UFM1 affects tumorous proliferation and immune response by impacting PD-L1 levels in triple-negative breast cancer.6
334301252021The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I.4
342990072021A Concerted Action of UBA5 C-Terminal Unstructured Regions Is Important for Transfer of Activated UFM1 to UFC1.4
345088582021Structure and dynamics of UBA5-UFM1 complex formation showing new insights in the UBA5 activation mechanism.0

Citation

Dessen P

UFM1 (ubiquitin fold modifier 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75461