UQCRQ (ubiquinol-cytochrome c reductase complex III subunit VII)

2014-11-01 Affiliation

Identity

HGNC

UQCRQ

LOCATION

5q31.1

LOCUSID

27089

ALIAS

MC3DN4,QCR8,QP-C,QPC,UQCR7

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 27089
MIM: 612080
HGNC: 29594
Ensembl: ENSG00000164405

Variants:

dbSNP: 27089
ClinVar: 27089
TCGA: ENSG00000164405
COSMIC: UQCRQ

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000164405	ENST00000378665	O14949
ENSG00000164405	ENST00000378667	O14949
ENSG00000164405	ENST00000378670	O14949

Expression (GTEx)

100

150

200

250

300

350

400

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Oxidative phosphorylation	KEGG	ko00190
Alzheimer's disease	KEGG	ko05010
Huntington's disease	KEGG	ko05016
Oxidative phosphorylation	KEGG	hsa00190
Alzheimer's disease	KEGG	hsa05010
Parkinson's disease	KEGG	hsa05012
Huntington's disease	KEGG	hsa05016
Cardiac muscle contraction	KEGG	hsa04260
Cardiac muscle contraction	KEGG	ko04260
Metabolic pathways	KEGG	hsa01100
Cytochrome bc1 complex	KEGG	hsa_M00152
Cytochrome bc1 complex	KEGG	M00152
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
Metabolism	REACTOME	R-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transport	REACTOME	R-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	REACTOME	R-HSA-163200
Respiratory electron transport	REACTOME	R-HSA-611105

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35877019	2023	Identification of Metabolic Syndrome-Related miRNA-mRNA Regulatory Networks and Key Genes Based on Bioinformatics Analysis.	0
35877019	2023	Identification of Metabolic Syndrome-Related miRNA-mRNA Regulatory Networks and Key Genes Based on Bioinformatics Analysis.	0
25950827	2015	Identification of Genes Expressed in Hyperpigmented Skin Using Meta-Analysis of Microarray Data Sets.	5
25950827	2015	Identification of Genes Expressed in Hyperpigmented Skin Using Meta-Analysis of Microarray Data Sets.	5
20440543	2010	Mitochondrial respiratory chain in the colonic mucosal of patients with ulcerative colitis.	51
20877624	2010	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	20
20440543	2010	Mitochondrial respiratory chain in the colonic mucosal of patients with ulcerative colitis.	51
20877624	2010	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	20
18439546	2008	Mitochondrial complex III deficiency associated with a homozygous mutation in UQCRQ.	42
18439546	2008	Mitochondrial complex III deficiency associated with a homozygous mutation in UQCRQ.	42

Citation

Dessen P

UQCRQ (ubiquinol-cytochrome c reductase complex III subunit VII)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75508