VPS25 (vacuolar protein sorting 25 homolog)

2014-11-01  

Identity

HGNC
VPS25
LOCATION
17q21.2
LOCUSID
84313
ALIAS
DERP9,EAP20,FAP20
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84313
MIM: 610907
HGNC: 28122
Ensembl: ENSG00000131475

Variants:

dbSNP: 84313
ClinVar: 84313
TCGA: ENSG00000131475
COSMIC: VPS25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131475ENST00000253794Q9BRG1
ENSG00000131475ENST00000253794A0A024R1X3
ENSG00000131475ENST00000589520K7EKV4
ENSG00000131475ENST00000589577K7EP45
ENSG00000131475ENST00000590339K7ENE3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
ESCRT-II complexKEGGhsa_M00410
ESCRT-II complexKEGGM00410
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Endosomal Sorting Complex Required For Transport (ESCRT)REACTOMER-HSA-917729

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
196866842009Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis.70
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
196866842009Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis.70
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
163713482006Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII.78
163713482006Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII.78

Citation

Dessen P

VPS25 (vacuolar protein sorting 25 homolog)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75629