BCAS4 (breast carcinoma amplified sequence 4)

2004-05-01   Jean-Loup Huret  , Sylvie Senon  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
20q13.13
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
CNOL
FUSION GENES

DNA/RNA

Description

spans 82 kb; orientation direct strand; 19 exons

Transcription

alternate splicings

Proteins

Expression

ubiquitous

Localisation

cytoplasmic

Implicated in

Entity name
BCAS4 is overexpressed in 3.5% of breast cancers, and a hybrid gene BCAS4-BCAS3 was found in breat cancer cell line with a t(17;20)(q23;q13)
Hybrid gene
5 BCAS4 is fused to the 2 last exons (23 and 24) of BCAS3; transcript includes exon 1 from BCAS4 and 21 bp from BCAS3 exon 23; it encodes a 66 aminoacids protein; no reciprocal transcript

Article Bibliography

Pubmed IDLast YearTitleAuthors
146340232004p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation.Melino G et al

Other Information

Locus ID:

NCBI: 55653
MIM: 607471
HGNC: 14367
Ensembl: ENSG00000124243

Variants:

dbSNP: 55653
ClinVar: 55653
TCGA: ENSG00000124243
COSMIC: BCAS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124243ENST00000358791Q8TDM0
ENSG00000124243ENST00000371608Q8TDM0
ENSG00000124243ENST00000445038A0A0C4DH49
ENSG00000124243ENST00000463943H7C4Y8
ENSG00000124243ENST00000609336A0A0C4DGS6

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
123785252002Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer.52
123785252002Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer.52

Citation

Jean-Loup Huret ; Sylvie Senon

BCAS4 (breast carcinoma amplified sequence 4)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/767/case-report-explorer/gene-fusions-explorer/tumors-explorer/