GCN1 (GCN1 activator of EIF2AK4)

2015-09-01  

Identity

HGNC
GCN1
LOCATION
12q24.23
LOCUSID
10985
ALIAS
GCN1L,GCN1L1,PRIC295
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10985
MIM: 605614
HGNC: 4199
Ensembl: ENSG00000089154

Variants:

dbSNP: 10985
ClinVar: 10985
TCGA: ENSG00000089154
COSMIC: GCN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089154ENST00000300648Q92616

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384742432024Emerging Role of GCN1 in Disease and Homeostasis.0
384742432024Emerging Role of GCN1 in Disease and Homeostasis.0
366387932023An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.13
366387932023An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.13
316801232020The genomic and clinical landscape of fetal akinesia.17
316801232020The genomic and clinical landscape of fetal akinesia.17
258083242015Interactome analysis of herpes simplex virus 1 envelope glycoprotein H.3
258083242015Interactome analysis of herpes simplex virus 1 envelope glycoprotein H.3

Citation

Dessen P

GCN1 (GCN1 activator of EIF2AK4)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/77727