ETFBKMT (electron transfer flavoprotein subunit beta lysine methyltransferase)

2016-01-01  

Identity

HGNC
ETFBKMT
LOCATION
12p11.21
LOCUSID
254013
ALIAS
C12orf72,ETFB-KMT,METTL20
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 254013
MIM: 615256
HGNC: 28739
Ensembl: ENSG00000139160

Variants:

dbSNP: 254013
ClinVar: 254013
TCGA: ENSG00000139160
COSMIC: ETFBKMT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139160ENST00000357721Q8IXQ9
ENSG00000139160ENST00000395763Q8IXQ9
ENSG00000139160ENST00000412352Q8IXQ9
ENSG00000139160ENST00000538391G5EA40
ENSG00000139160ENST00000538463Q8IXQ9
ENSG00000139160ENST00000539633F5H481

Expression (GTEx)

0
1
2
3
4
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Protein methylationREACTOMER-HSA-8876725

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
293522212018Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions.13
293522212018Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions.13
254167812015Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity.34
254167812015Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity.34
250232812014Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria.36
250232812014Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria.36
229488202012Lysine methylation of VCP by a member of a novel human protein methyltransferase family.75
229488202012Lysine methylation of VCP by a member of a novel human protein methyltransferase family.75

Citation

Dessen P

ETFBKMT (electron transfer flavoprotein subunit beta lysine methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/77830