SRPRA (SRP receptor subunit alpha)

2016-01-01 Affiliation

Identity

HGNC

SRPRA

LOCATION

11q24.2

LOCUSID

6734

ALIAS

DP,SRPR,Sralpha

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6734
MIM: 182180
HGNC: 11307
Ensembl: ENSG00000182934

Variants:

dbSNP: 6734
ClinVar: 6734
TCGA: ENSG00000182934
COSMIC: SRPRA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000182934	ENST00000332118	P08240
ENSG00000182934	ENST00000532259	P08240

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Protein export	KEGG	ko03060
Protein export	KEGG	hsa03060
Metabolism of proteins	REACTOME	R-HSA-392499
Translation	REACTOME	R-HSA-72766
SRP-dependent cotranslational protein targeting to membrane	REACTOME	R-HSA-1799339
Unfolded Protein Response (UPR)	REACTOME	R-HSA-381119
IRE1alpha activates chaperones	REACTOME	R-HSA-381070
XBP1(S) activates chaperone genes	REACTOME	R-HSA-381038
Gene Expression	REACTOME	R-HSA-74160

References

Pubmed ID	Year	Title	Citations
36223592	2023	Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes.	8
36223592	2023	Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes.	8

Citation

Dessen P

SRPRA (SRP receptor subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/78019