AGR3 (anterior gradient 3, protein disulphide isomerase family member)

2003-10-01  

Identity

HGNC
AGR3
LOCATION
7p21.1
LOCUSID
155465
ALIAS
AG-3,AG3,BCMP11,HAG3,PDIA18,hAG-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 155465
MIM: 609482
HGNC: 24167
Ensembl: ENSG00000173467

Variants:

dbSNP: 155465
ClinVar: 155465
TCGA: ENSG00000173467
COSMIC: AGR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173467ENST00000310398Q8TD06
ENSG00000173467ENST00000402239B5MC62
ENSG00000173467ENST00000414935H7C040

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365930092023Over-expression of Anterior Gradient 3 Is Associated With Tumor Progression and Poor Survival in Gastric Cancer.0
379449282023Prognostic Impact of AGR3 Protein Expression in Breast Cancer: A Systematic Review and Meta-analysis.0
365930092023Over-expression of Anterior Gradient 3 Is Associated With Tumor Progression and Poor Survival in Gastric Cancer.0
379449282023Prognostic Impact of AGR3 Protein Expression in Breast Cancer: A Systematic Review and Meta-analysis.0
358579282022Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer.5
358579282022Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer.5
339171632021Anterior Gradient Protein 3 and S100 Calcium-Binding Protein P Levels in Different Endometrial Epithelial Compartments May Play an Important Role in Recurrent Pregnancy Failure.7
340571172021Profile of anterior gradient 3 (AGR3) mRNA expression and serum levels in benign and malignant breast tumors.2
345199052021Estrogen-regulated AGR3 activates the estrogen receptor signaling pathway to promote tamoxifen resistance in breast cancer.2
339171632021Anterior Gradient Protein 3 and S100 Calcium-Binding Protein P Levels in Different Endometrial Epithelial Compartments May Play an Important Role in Recurrent Pregnancy Failure.7
340571172021Profile of anterior gradient 3 (AGR3) mRNA expression and serum levels in benign and malignant breast tumors.2
345199052021Estrogen-regulated AGR3 activates the estrogen receptor signaling pathway to promote tamoxifen resistance in breast cancer.2
315268292020AGR3 promotes the stemness of colorectal cancer via modulating Wnt/β-catenin signalling.9
315268292020AGR3 promotes the stemness of colorectal cancer via modulating Wnt/β-catenin signalling.9
296201962018Combination of TP53 and AGR3 to distinguish ovarian high-grade serous carcinoma from low-grade serous carcinoma.3

Citation

Dessen P

AGR3 (anterior gradient 3, protein disulphide isomerase family member)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/783/favicon/teaching-explorer/teaching-explorer/