HPF1 (histone PARylation factor 1)

2001-01-01  

Identity

HGNC
HPF1
LOCATION
4q33
LOCUSID
54969
ALIAS
C4orf27

Other Information

Locus ID:

NCBI: 54969
MIM: 616614
HGNC: 26051
Ensembl: ENSG00000056050

Variants:

dbSNP: 54969
ClinVar: 54969
TCGA: ENSG00000056050
COSMIC: HPF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000056050ENST00000393381Q9NWY4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375417862023Germline HPF1 retrogene insertion in RB1 gene involved in cancer predisposition.0
375417862023Germline HPF1 retrogene insertion in RB1 gene involved in cancer predisposition.0
335896102021HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.31
336831972021HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase.33
342109652021Serine-linked PARP1 auto-modification controls PARP inhibitor response.40
346255442021The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome.39
347328252021Dual function of HPF1 in the modulation of PARP1 and PARP2 activities.9
347952602021HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.30
335896102021HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.31
336831972021HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase.33
342109652021Serine-linked PARP1 auto-modification controls PARP inhibitor response.40
346255442021The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome.39
347328252021Dual function of HPF1 in the modulation of PARP1 and PARP2 activities.9
347952602021HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.30
320285272020HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.126

Citation

Dessen P

HPF1 (histone PARylation factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2001-01-01

Online version: http://atlasgeneticsoncology.org/gene/78372