MLX (MAX dimerization protein MLX)

2001-01-01 Affiliation

Identity

HGNC

MLX

LOCATION

17q21.2

LOCUSID

6945

ALIAS

MAD7,MXD7,TCFL4,TF4,bHLHd13

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6945
MIM: 602976
HGNC: 11645
Ensembl: ENSG00000108788

Variants:

dbSNP: 6945
ClinVar: 6945
TCGA: ENSG00000108788
COSMIC: MLX

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000108788	ENST00000246912	Q9UH92
ENSG00000108788	ENST00000346833	Q9UH92
ENSG00000108788	ENST00000435881	Q9UH92
ENSG00000108788	ENST00000591024	K7EID0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
ChREBP activates metabolic gene expression	REACTOME	R-HSA-163765
Insulin resistance	KEGG	hsa04931

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37088121	2023	MLX plays a key role in lipid and glucose metabolism in humans: Evidence from in vitro and in vivo studies.	1
37088121	2023	MLX plays a key role in lipid and glucose metabolism in humans: Evidence from in vitro and in vivo studies.	1
31919096	2020	The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells.	8
31919096	2020	The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells.	8
30354298	2018	Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis.	8
30354298	2018	Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis.	8
24857747	2015	Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.	67
25640402	2015	Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.	116
24857747	2015	Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.	67
25640402	2015	Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.	116
18458340	2008	Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.	151
18458340	2008	Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.	151
16782875	2006	MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis.	68
16782875	2006	MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis.	68
15664996	2005	Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.	80

Citation

Dessen P

MLX (MAX dimerization protein MLX)

Atlas Genet Cytogenet Oncol Haematol. 2001-01-01

Online version: http://atlasgeneticsoncology.org/gene/78577