BECN1 (beclin 1)

2003-02-01  

Identity

HGNC
BECN1
LOCATION
17q21.31
LOCUSID
8678
ALIAS
ATG6,VPS30,beclin1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8678
MIM: 604378
HGNC: 1034
Ensembl: ENSG00000126581

Variants:

dbSNP: 8678
ClinVar: 8678
TCGA: ENSG00000126581
COSMIC: BECN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126581ENST00000361523Q14457
ENSG00000126581ENST00000361523A0A024R1X5
ENSG00000126581ENST00000438274E7EV84
ENSG00000126581ENST00000586589K7ELY9
ENSG00000126581ENST00000587880K7EL88
ENSG00000126581ENST00000588276K7EMA2
ENSG00000126581ENST00000589636K7EQQ7
ENSG00000126581ENST00000589663K7ER46
ENSG00000126581ENST00000590099Q14457
ENSG00000126581ENST00000590099A0A024R1X5
ENSG00000126581ENST00000590764K7ES83
ENSG00000126581ENST00000590852K7ERY0
ENSG00000126581ENST00000591085K7EKK2
ENSG00000126581ENST00000593205K7EN35
ENSG00000126581ENST00000612631A0A087WVZ2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Apoptosis - multiple speciesKEGGko04215
Apoptosis - multiple speciesKEGGhsa04215
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Apelin signaling pathwayKEGGhsa04371
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381776732024Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging.0
381825632024GRB2 is a BECN1 interacting protein that regulates autophagy.1
382116532024Targeting IL-6/STAT3 signaling abrogates EGFR-TKI resistance through inhibiting Beclin-1 dependent autophagy in HNSCC.1
383609972024VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation.1
383968162024THSD1 Suppresses Autophagy-Mediated Focal Adhesion Turnover by Modulating the FAK-Beclin 1 Pathway.0
385140652024Upregulation of miR-499a Targets Beclin1 to Modulate Astrocyte Autophagy and Promote Ischemic Stroke.0
381776732024Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging.0
381825632024GRB2 is a BECN1 interacting protein that regulates autophagy.1
382116532024Targeting IL-6/STAT3 signaling abrogates EGFR-TKI resistance through inhibiting Beclin-1 dependent autophagy in HNSCC.1
383609972024VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation.1
383968162024THSD1 Suppresses Autophagy-Mediated Focal Adhesion Turnover by Modulating the FAK-Beclin 1 Pathway.0
385140652024Upregulation of miR-499a Targets Beclin1 to Modulate Astrocyte Autophagy and Promote Ischemic Stroke.0
356998252023Upregulation of necroptosis markers RIPK3/MLKL and their crosstalk with autophagy-related protein Beclin-1 in primary immune thrombocytopenia.0
365864622023GAPR-1 Interferes with Condensate Formation of Beclin 1 in Saccharomyces cerevisiae.1
370407702023Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy.4

Citation

Dessen P

BECN1 (beclin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/786