PIP4P1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1)

2017-09-01  

Identity

HGNC
PIP4P1
LOCATION
14q11.2
LOCUSID
90809
ALIAS
C14orf9,TMEM55B

Other Information

Locus ID:

NCBI: 90809
MIM: 609865
HGNC: 19299
Ensembl: ENSG00000165782

Variants:

dbSNP: 90809
ClinVar: 90809
TCGA: ENSG00000165782
COSMIC: PIP4P1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165782ENST00000250489Q86T03
ENSG00000165782ENST00000398020Q86T03
ENSG00000165782ENST00000553460H0YJ90
ENSG00000165782ENST00000556093G3V5T5

Pathways

PathwaySourceExternal ID
Phosphatidylinositol signaling systemKEGGko04070
Phosphatidylinositol signaling systemKEGGhsa04070
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758
PI5P Regulates TP53 AcetylationREACTOMER-HSA-6811555
Synthesis of PIPs in the nucleusREACTOMER-HSA-8847453

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
335377192021Regulation of lysosomal positioning via TMEM55B phosphorylation.2
335377192021Regulation of lysosomal positioning via TMEM55B phosphorylation.2
296447702018TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation.15
296447702018TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation.15
291469372017TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.88
291469372017TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.88
250353452014Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism.11
250353452014Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism.11
179400112007Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.35
179400112007Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.35
163652872005The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.45
163652872005The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.45

Citation

Dessen P

PIP4P1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-09-01

Online version: http://atlasgeneticsoncology.org/gene/79420