BTG4 (BTG anti-proliferation factor 4)

2003-02-01  

Identity

HGNC
BTG4
LOCATION
11q23.1
LOCUSID
54766
ALIAS
APRO3,OOMD8,PC3B

Other Information

Locus ID:

NCBI: 54766
MIM: 605673
HGNC: 13862
Ensembl: ENSG00000137707

Variants:

dbSNP: 54766
ClinVar: 54766
TCGA: ENSG00000137707
COSMIC: BTG4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137707ENST00000356018Q9NY30
ENSG00000137707ENST00000456861E9PRM5
ENSG00000137707ENST00000525791Q9NY30

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018

References

Pubmed IDYearTitleCitations
364712032023A novel homozygous C-terminal deletion in BTG4 causes zygotic cleavage failure and female infertility.0
364712032023A novel homozygous C-terminal deletion in BTG4 causes zygotic cleavage failure and female infertility.0
346472282021A novel homozygous missense variant in BTG4 causes zygotic cleavage failure and female infertility.1
346472282021A novel homozygous missense variant in BTG4 causes zygotic cleavage failure and female infertility.1
320930412020BTG4 is A Novel p53 Target Gene That Inhibits Cell Growth and Induces Apoptosis.6
325023912020Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility.31
320930412020BTG4 is A Novel p53 Target Gene That Inhibits Cell Growth and Induces Apoptosis.6
325023912020Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility.31
203099402011A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma.77
203099402011A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma.77
195761782009Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer.11
195761782009Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer.11
185196712008Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.245
185196712008Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.245
156724092005Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia.14

Citation

Dessen P

BTG4 (BTG anti-proliferation factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/850