TSPO (translocator protein)

2003-06-01  

Identity

HGNC
TSPO
LOCATION
22q13.2
LOCUSID
706
ALIAS
BPBS,BZRP,DBI,IBP,MBR,PBR,PBS,PKBS,PTBR,mDRC,pk18
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 706
MIM: 109610
HGNC: 1158
Ensembl: ENSG00000100300

Variants:

dbSNP: 706
ClinVar: 706
TCGA: ENSG00000100300
COSMIC: TSPO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100300ENST00000329563P30536
ENSG00000100300ENST00000337554P30536
ENSG00000100300ENST00000396265B1AH88
ENSG00000100300ENST00000396265P30536
ENSG00000100300ENST00000428336B1AH87
ENSG00000100300ENST00000583777J3QLD3

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378011392024Integrating TSPO PET imaging and transcriptomics to unveil the role of neuroinflammation and amyloid-β deposition in Alzheimer's disease.3
378011392024Integrating TSPO PET imaging and transcriptomics to unveil the role of neuroinflammation and amyloid-β deposition in Alzheimer's disease.3
369733852023Investigating TSPO levels in occupation-related posttraumatic stress disorder.0
369802952023Impact of Translocator Protein 18 kDa (TSPO) Deficiency on Mitochondrial Function and the Inflammatory State of Human C20 Microglia Cells.1
370473532023Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97.3
371589622023TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma.1
372914482023[(18)F]DPA-714: Effect of co-medications, age, sex, BMI and TSPO polymorphism on the human plasma input function.2
375747312023TSPO Modulates Oligomeric Amyloid-β-Induced Monocyte Chemotaxis: Relevance for Neuroinflammation in Alzheimer's Disease.2
375807672023The mitochondrial protein TSPO in Alzheimer's disease: relation to the severity of AD pathology and the neuroinflammatory environment.4
379522212023Translocator protein (TSPO) expression in neoplastic cells and tumor-associated macrophages in meningiomas.0
369733852023Investigating TSPO levels in occupation-related posttraumatic stress disorder.0
369802952023Impact of Translocator Protein 18 kDa (TSPO) Deficiency on Mitochondrial Function and the Inflammatory State of Human C20 Microglia Cells.1
370473532023Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97.3
371589622023TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma.1
372914482023[(18)F]DPA-714: Effect of co-medications, age, sex, BMI and TSPO polymorphism on the human plasma input function.2

Citation

Dessen P

TSPO (translocator protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/858