THOC5 (THO complex 5)

2003-06-01 Affiliation

Identity

HGNC

THOC5

LOCATION

22q12.2

LOCUSID

8563

ALIAS

C22orf19,Fmip,PK1.3,fSAP79

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8563
MIM: 612733
HGNC: 19074
Ensembl: ENSG00000100296

Variants:

dbSNP: 8563
ClinVar: 8563
TCGA: ENSG00000100296
COSMIC: THOC5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100296	ENST00000358079	F5GZF3
ENSG00000100296	ENST00000397871	Q13769
ENSG00000100296	ENST00000397871	A0A024R1D6
ENSG00000100296	ENST00000397872	Q13769
ENSG00000100296	ENST00000397872	A0A024R1D6
ENSG00000100296	ENST00000397873	Q13769
ENSG00000100296	ENST00000397873	A0A024R1D6
ENSG00000100296	ENST00000414902	F8WES8
ENSG00000100296	ENST00000418021	C9JXU6
ENSG00000100296	ENST00000428374	C9JCL9
ENSG00000100296	ENST00000440771	C9JXG5
ENSG00000100296	ENST00000442555	F8WCP5
ENSG00000100296	ENST00000443089	H7C072
ENSG00000100296	ENST00000455450	H7C441
ENSG00000100296	ENST00000490103	Q13769
ENSG00000100296	ENST00000490103	A0A024R1D6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RNA transport	KEGG	ko03013
RNA transport	KEGG	hsa03013
THC complex	KEGG	hsa_M00405
TREX complex	KEGG	hsa_M00406
THC complex	KEGG	M00405
TREX complex	KEGG	M00406
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Transcription Termination	REACTOME	R-HSA-73856
Cleavage of Growing Transcript in the Termination Region	REACTOME	R-HSA-109688
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
mRNA 3'-end processing	REACTOME	R-HSA-72187
Transport of Mature Transcript to Cytoplasm	REACTOME	R-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing Transcript	REACTOME	R-HSA-159236

References

Pubmed ID	Year	Title	Citations
35688054	2022	THOC5 regulates human osteoclastogenesis.	0
35688054	2022	THOC5 regulates human osteoclastogenesis.	0
33483601	2021	RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization.	21
33483601	2021	RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization.	21
31402763	2020	Polymorphism of the THOC5 of the transcription/export multiprotein complex and its correlation with the lipid and metabolic profile in middle-aged women.	2
32065701	2020	Human THO maintains the stability of repetitive DNA.	3
31402763	2020	Polymorphism of the THOC5 of the transcription/export multiprotein complex and its correlation with the lipid and metabolic profile in middle-aged women.	2
32065701	2020	Human THO maintains the stability of repetitive DNA.	3
30721563	2019	Human THO coordinates transcription termination and subsequent transcript release from the HSP70 locus.	3
30721563	2019	Human THO coordinates transcription termination and subsequent transcript release from the HSP70 locus.	3
26549021	2016	Depletion of three combined THOC5 mRNA export protein target genes synergistically induces human hepatocellular carcinoma cell death.	13
26549021	2016	Depletion of three combined THOC5 mRNA export protein target genes synergistically induces human hepatocellular carcinoma cell death.	13
23032722	2013	A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.	15
23685434	2013	Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I.	36
24023261	2013	THOC5: a novel gene involved in HDL-cholesterol metabolism.	7

Citation

Dessen P

THOC5 (THO complex 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/884