CA9 (carbonic anhydrase 9)

2003-06-01  

Identity

HGNC
LOCATION
9p13.3
LOCUSID
ALIAS
CAIX,MN

Other Information

Locus ID:

NCBI: 768
MIM: 603179
HGNC: 1383
Ensembl: ENSG00000107159

Variants:

dbSNP: 768
ClinVar: 768
TCGA: ENSG00000107159
COSMIC: CA9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107159ENST00000378357Q16790
ENSG00000107159ENST00000378357A0A0S2Z3D0
ENSG00000107159ENST00000617161A0A087WYS4

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
Nitrogen metabolismKEGGko00910
Nitrogen metabolismKEGGhsa00910
MetabolismREACTOMER-HSA-1430728
Reversible hydration of carbon dioxideREACTOMER-HSA-1475029
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to hypoxiaREACTOMER-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygenREACTOMER-HSA-1234174
Regulation of gene expression by Hypoxia-inducible FactorREACTOMER-HSA-1234158

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448871celecoxibChemicalPathwayassociated22336956

References

Pubmed IDYearTitleCitations
376816722024Spatial transcriptomic analysis of tumour with high and low CAIX expression in TNBC tissue samples using GeoMx™ RNA assay.0
381771542024LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma.1
386274292024Aerobic vaginitis is associated with carbonic anhydrase IX in cervical intraepithelial neoplasia.0
387668572024Unlocking the paracrine crosstalk: adipocyte-derived factors affect carbonic anhydrase IX expression in colon and breast cancer cells.0
388393632024Epigenetic Regulation of Carbonic Anhydrase 9 Expression by Nitric Oxide in Human Small Airway Epithelial Cells.0
376816722024Spatial transcriptomic analysis of tumour with high and low CAIX expression in TNBC tissue samples using GeoMx™ RNA assay.0
381771542024LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma.1
386274292024Aerobic vaginitis is associated with carbonic anhydrase IX in cervical intraepithelial neoplasia.0
387668572024Unlocking the paracrine crosstalk: adipocyte-derived factors affect carbonic anhydrase IX expression in colon and breast cancer cells.0
388393632024Epigenetic Regulation of Carbonic Anhydrase 9 Expression by Nitric Oxide in Human Small Airway Epithelial Cells.0
364765992023Carbonic Anhydrase IX (CAIX) Expressing Hypoxic Micro-environment Hampers CD8+ Immune Cell Infiltrate in Breast Carcinoma.0
365243672023ADAM10 mediates shedding of carbonic anhydrase IX ectodomain non‑redundantly to ADAM17.1
365376082023IGFL2-AS1-induced suppression of HIF-1α degradation promotes cell proliferation and invasion in colorectal cancer by upregulating CA9.4
369017562023Carbonic Anhydrase IX in Tumor Tissue and Plasma of Breast Cancer Patients: Reliable Biomarker of Hypoxia and Prognosis.2
370470962023CA-IX-Expressing Small Extracellular Vesicles (sEVs) Are Released by Melanoma Cells under Hypoxia and in the Blood of Advanced Melanoma Patients.2

Citation

Dessen P

CA9 (carbonic anhydrase 9)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/898/ca9